8OH8

Crystal structure of the cysteine-rich Gallus gallus urate oxidase in complex with the 8-azaxanthine inhibitor under reducing conditions (space group P 21 21 21)

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (AAA, BBB, CCC, DDD)	Uricase	polymer	343	39109.9	4	UniProt (A0A8V0ZED1) Pfam (PF01014)	Gallus gallus (chicken)	Urate oxidase
2	AA, E, O, V (DDD, AAA, BBB, CCC)	8-AZAXANTHINE	non-polymer		153.1	4	Chemie (AZA)
3	BA, CA, DA, EA, F... (DDD, AAA, BBB, CCC)	1,2-ETHANEDIOL	non-polymer		62.1	23	Chemie (EDO)
4	IA, M (DDD, AAA)	D(-)-TARTARIC ACID	non-polymer		150.1	2	Chemie (TAR)
5	N, W (BBB, CCC)	OXYGEN MOLECULE	non-polymer		32.0	2	Chemie (OXY)
6	JA, KA (DDD)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
7	LA, MA, NA, OA (AAA, BBB, CCC, DDD)	water	water		18.0	434	Chemie (HOH)

Sequence modifications

AAA, BBB, CCC, DDD: 1 - 320 (UniProt: A0A8V0ZED1)

PDB	External Database	Details
Met -22	-	initiating methionine
Gly -21	-	expression tag
Ser -20	-	expression tag
Ser -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
Ser -12	-	expression tag
Ser -11	-	expression tag
Gly -10	-	expression tag
Leu -9	-	expression tag
Val -8	-	expression tag
Pro -7	-	expression tag
Arg -6	-	expression tag
Gly -5	-	expression tag
Ser -4	-	expression tag
His -3	-	expression tag
Met -2	-	expression tag
Ala -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	156439.5
Non-Polymers*	Number of molecules	33
	Total formula weight	2475.0
All*	Total formula weight	158914.6

*Water molecules are not included.