8OGA
Crystal structure of human DCAF1 WD40 repeats (Q1250L) in complex with compound 6
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | P | DDB1- and CUL4-associated factor 1 | polymer | 318 | 36062.6 | 1 | UniProt (Q9Y4B6) In PDB | Homo sapiens (human) | HIV-1 Vpr-binding protein,VprBP,Serine/threonine-protein kinase VPRBP,Vpr-interacting protein |
| 2 | P | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 3 | P | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
| 4 | P | 5-[1-(4-methoxyphenyl)cyclopropyl]-8-(4-methylpiperazin-1-yl)-2,3-dihydroimidazo[2,1-a]isoquinoline | non-polymer | 414.5 | 1 | Chemie (VLW) | |||
| 5 | water | water | 18.0 | 57 | Chemie (HOH) |
Sequence modifications
P: 1079 - 1393 (UniProt: Q9Y4B6)
| PDB | External Database | Details |
|---|---|---|
| Gly 1076 | - | expression tag |
| Gly 1077 | - | expression tag |
| Gly 1078 | - | expression tag |
| Leu 1250 | Gln 1250 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36062.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 757.0 | |
| All* | Total formula weight | 36819.6 |
