8OG5
Crystal structure of human DCAF1 WD40 repeats (Q1250L) in complex with compound 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | DDB1- and CUL4-associated factor 1 | polymer | 367 | 41764.8 | 1 | UniProt (Q9Y4B6) In PDB | Homo sapiens (human) | HIV-1 Vpr-binding protein,VprBP,Serine/threonine-protein kinase VPRBP,Vpr-interacting protein |
| 2 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 3 | A | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 4 | A | 5-(2-fluorophenyl)-2,3-dihydroimidazo[2,1-a]isoquinoline | non-polymer | 264.3 | 3 | Chemie (LQH) | |||
| 5 | water | water | 18.0 | 207 | Chemie (HOH) |
Sequence modifications
A: 1039 - 1401 (UniProt: Q9Y4B6)
| PDB | External Database | Details |
|---|---|---|
| Gly 1035 | - | expression tag |
| Gly 1036 | - | expression tag |
| Gly 1037 | - | expression tag |
| Arg 1038 | - | expression tag |
| Leu 1250 | Gln 1250 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41764.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 914.0 | |
| All* | Total formula weight | 42678.8 |
