8OFA
Crystal structure of human cathepsin L interacting with tosyl phenylalanyl chloromethyl ketone (TPCK)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Cathepsin L | polymer | 220 | 24161.7 | 4 | UniProt (P07711) Pfam (PF00112) | Homo sapiens (human) | |
| 2 | BA, E, O, U (D, A, B, C) | N-[(2S)-4-chloro-3-oxo-1-phenyl-butan-2-yl]-4-methyl-benzenesulfonamide | non-polymer | 351.8 | 4 | Chemie (TQ8) | |||
| 3 | AA, EA, F, GA, HA... (C, D, A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 7 | Chemie (EDO) | |||
| 4 | CA, G, M, P, V... (D, A, B, C) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 7 | Chemie (PEG) | |||
| 5 | DA, H, JA, K, L... (D, A, B, C) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 9 | Chemie (DMS) | |||
| 6 | FA, I, IA (D, A) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 3 | Chemie (PGE) | |||
| 7 | J (A) | 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE | non-polymer | 178.2 | 1 | Chemie (PG5) | |||
| 8 | LA, N (D, A) | 4-methyl-~{N}-[(2~{S})-4-oxidanyl-3-oxidanylidene-1-phenyl-butan-2-yl]benzenesulfonamide | non-polymer | 333.4 | 2 | Chemie (VLF) | |||
| 9 | S (B) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 10 | MA, NA, OA, PA (A, B, C, D) | water | water | 18.0 | 556 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 220 (UniProt: P07711)
| PDB | External Database | Details |
|---|---|---|
| Ala 110 | Thr 223 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 96646.7 | |
| Non-Polymers* | Number of molecules | 34 |
| Total formula weight | 4642.5 | |
| All* | Total formula weight | 101289.2 |
