8KDD
Structure of LAT1-CD98hc-Fab170 in complex with JPH203, consensus map
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 4F2 cell-surface antigen heavy chain | polymer | 631 | 68069.6 | 1 | UniProt (P08195) Pfam (PF16028) Pfam (PF00128) | Homo sapiens (human) | Glycoprotein, 4F2hc,4F2 heavy chain antigen,Lymphocyte activation antigen 4F2 large subunit,Solute carrier family 3 member 2 |
| 2 | B (B) | Large neutral amino acids transporter small subunit 1 | polymer | 515 | 56043.7 | 1 | UniProt (Q01650) Pfam (PF13520) | Homo sapiens (human) | 4F2 light chain,4F2LC,CD98 light chain,Integral membrane protein E16,L-type amino acid transporter 1,hLAT1,Solute carrier family 7 member 5,y+ system cationic amino acid transporter |
| 3 | C (L) | Fab170 light chain | polymer | 220 | 24356.0 | 1 | Mus musculus | ||
| 4 | D (H) | Fab170 heavy chain | polymer | 230 | 24981.9 | 1 | Mus musculus | ||
| 5 | E, F, G, H (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 6 | I (B) | Nanvuranlat | non-polymer | 472.3 | 1 | Chemie (VRW) |
Sequence modifications
A: 2 - 630 (UniProt: P08195)
B: 1 - 507 (UniProt: Q01650)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asp 508 | - | expression tag |
| Tyr 509 | - | expression tag |
| Lys 510 | - | expression tag |
| Asp 511 | - | expression tag |
| Asp 512 | - | expression tag |
| Asp 513 | - | expression tag |
| Asp 514 | - | expression tag |
| Lys 515 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 173451.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1357.2 | |
| All* | Total formula weight | 174808.4 |
