8KCP

Cryo-EM structure of human gamma-secretase in complex with Crenigacestat

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Nicastrin	polymer	701	77622.6	1	UniProt (Q92542) Pfam (PF18266) Pfam (PF05450)	Homo sapiens (human)
2	B (B)	Presenilin-1	polymer	467	52713.5	1	UniProt (P49768) Pfam (PF01080)	Homo sapiens (human)	PS-1,Protein S182
3	C (C)	Gamma-secretase subunit APH-1A	polymer	265	29017.9	1	UniProt (Q96BI3) Pfam (PF06105)	Homo sapiens (human)	APH-1a,Aph-1alpha,Presenilin-stabilization factor
4	D (D)	Gamma-secretase subunit PEN-2	polymer	101	12038.0	1	UniProt (Q9NZ42) Pfam (PF10251)	Homo sapiens (human)	Presenilin enhancer protein 2
5	E, G, H, I, J (E, G, H, I, J)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	5	In PDB GlyTouCan (G42666HT)
6	F (F)	beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G89225LT)
7	K, L, M, N, O... (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)
8	Q, V (B, C)	1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE	non-polymer		790.1	2	Chemie (PC1)
9	R (B)	4,4,4-tris(fluoranyl)-N-[(2S)-1-[[(7S)-5-(2-hydroxyethyl)-6-oxidanylidene-7H-pyrido[2,3-d][3]benzazepin-7-yl]amino]-1-oxidanylidene-propan-2-yl]butanamide	non-polymer		464.4	1	Chemie (N9C)
10	S, T, U (C)	CHOLESTEROL	non-polymer		386.7	3	Chemie (CLR)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	171392.1
Branched	Number of molecules	6
	Total formula weight	3032.8
Non-Polymers*	Number of molecules	12
	Total formula weight	4531.9
All*	Total formula weight	178956.9

*Water molecules are not included.