8KCO
Cryo-EM structure of human gamma-secretase in complex with RO4929097
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Nicastrin | polymer | 701 | 77622.6 | 1 | UniProt (Q92542) Pfam (PF18266) Pfam (PF05450) In PDB | Homo sapiens (human) | |
2 | B | Presenilin-1 | polymer | 467 | 52713.5 | 1 | UniProt (P49768) Pfam (PF01080) In PDB | Homo sapiens (human) | PS-1,Protein S182 |
3 | C | Gamma-secretase subunit APH-1A | polymer | 265 | 29017.9 | 1 | UniProt (Q96BI3) Pfam (PF06105) In PDB | Homo sapiens (human) | APH-1a,Aph-1alpha,Presenilin-stabilization factor |
4 | D | Gamma-secretase subunit PEN-2 | polymer | 101 | 12038.0 | 1 | UniProt (Q9NZ42) Pfam (PF10251) In PDB | Homo sapiens (human) | Presenilin enhancer protein 2 |
5 | E, G, H, I, J | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
6 | F | beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G89225LT) | |||
7 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
8 | B | 2,2-dimethyl-N-[(7S)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide | non-polymer | 469.4 | 1 | Chemie (N60) | |||
9 | B, C | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 2 | Chemie (PC1) | |||
10 | C | CHOLESTEROL | non-polymer | 386.7 | 3 | Chemie (CLR) |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 171392.1 | |
Branched | Number of molecules | 6 |
Total formula weight | 3032.8 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 4536.9 | |
All* | Total formula weight | 178961.9 |