8K96

CryoEM structure of LonC protease hepatmer with Bortezomib

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (B, A, G, F, E...)	endopeptidase La	polymer	732	80558.4	7	UniProt (C9DRU9) Pfam (PF13654) Pfam (PF20436) Pfam (PF05362)	Meiothermus taiwanensis	LonC protease
2	H, J, L, N, P... (B, A, G, F, E...)	PHOSPHATE ION	non-polymer		95.0	7	Chemie (PO4)
3	I, K, M, O, Q... (B, A, G, F, E...)	N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE	non-polymer		384.2	7	Chemie (BO2)

Sequence modifications

B, A, G, F, E, D, C: 1 - 719 (UniProt: C9DRU9)

PDB	External Database	Details
Lys 720	-	expression tag
Leu 721	-	expression tag
Ala 722	-	expression tag
Ala 723	-	expression tag
Ala 724	-	expression tag
Leu 725	-	expression tag
Glu 726	-	expression tag
His 727	-	expression tag
His 728	-	expression tag
His 729	-	expression tag
His 730	-	expression tag
His 731	-	expression tag
His 732	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	7
	Total formula weight	563908.5
Non-Polymers*	Number of molecules	14
	Total formula weight	3354.5
All*	Total formula weight	567262.9

*Water molecules are not included.