8K8J
Cannabinoid Receptor 1 bound to Fenofibrate coupling MiniGsq and Nb35 Complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 263 | 30652.6 | 1 | UniProt (P63092) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-stimulating G alpha protein |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37416.9 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 97 | 10498.0 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
4 | N | Nanobody 35 | polymer | 139 | 15271.9 | 1 | Homo sapiens (human) | ||
5 | R | Soluble cytochrome b562,Cannabinoid receptor 1 | polymer | 525 | 59685.4 | 1 | UniProt (P0ABE7) UniProt (P21554) Pfam (PF07361) Pfam (PF00001) In PDB | Escherichia coli | Cytochrome b-562,CB-R,CB1,CANN6 |
6 | R | propan-2-yl 2-[4-(4-chlorophenyl)carbonylphenoxy]-2-methyl-propanoate | non-polymer | 360.8 | 1 | Chemie (J3O) |
Sequence modifications
A: 5 - 195 (UniProt: P63092)
A: 204 - 361 (UniProt: P63092)
G: 1 - 71 (UniProt: P59768)
R: -43 - 61 (UniProt: P0ABE7)
R: 71 - 425 (UniProt: P21554)
PDB | External Database | Details |
---|---|---|
Met -9 | - | initiating methionine |
Gly -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
Glu -1 | - | expression tag |
Asn 0 | - | expression tag |
Leu 1 | - | expression tag |
Tyr 2 | - | expression tag |
Phe 3 | - | expression tag |
Gln 4 | - | expression tag |
Asp 49 | Gly 49 | conflict |
Asn 50 | Glu 50 | conflict |
PDB | External Database | Details |
---|---|---|
Gly 196 | - | linker |
Gly 197 | - | linker |
Ser 198 | - | linker |
Gly 199 | - | linker |
Gly 200 | - | linker |
Ser 201 | - | linker |
Gly 202 | - | linker |
Gly 203 | - | linker |
Asp 249 | Ala 235 | conflict |
Asp 252 | Ser 238 | conflict |
- | Asn 240 | deletion |
- | Met 241 | deletion |
- | Val 242 | deletion |
- | Ile 243 | deletion |
- | Arg 244 | deletion |
- | Glu 245 | deletion |
- | Asp 246 | deletion |
- | Asn 247 | deletion |
- | Gln 248 | deletion |
- | Thr 249 | deletion |
Ala 362 | - | expression tag |
Arg 363 | - | expression tag |
Arg 364 | - | expression tag |
Ile 365 | - | expression tag |
Phe 366 | - | expression tag |
Asn 367 | - | expression tag |
Asp 368 | - | expression tag |
Cys 369 | - | expression tag |
Lys 370 | - | expression tag |
Asp 371 | - | expression tag |
Ile 372 | - | expression tag |
Ile 373 | - | expression tag |
Leu 374 | - | expression tag |
Gln 375 | - | expression tag |
Met 376 | - | expression tag |
Asn 377 | - | expression tag |
Leu 378 | - | expression tag |
Arg 379 | - | expression tag |
Glu 380 | - | expression tag |
Tyr 381 | - | expression tag |
Asn 382 | - | expression tag |
Leu 383 | - | expression tag |
Val 384 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -25 | - | initiating methionine |
His -24 | - | expression tag |
His -23 | - | expression tag |
His -22 | - | expression tag |
His -21 | - | expression tag |
His -20 | - | expression tag |
His -19 | - | expression tag |
Gly -18 | - | expression tag |
Gly -17 | - | expression tag |
Gly -16 | - | expression tag |
Ser -15 | - | expression tag |
Asp -14 | - | expression tag |
Ser -13 | - | expression tag |
Leu -12 | - | expression tag |
Glu -11 | - | expression tag |
Phe -10 | - | expression tag |
Ile -9 | - | expression tag |
Ala -8 | - | expression tag |
Ser -7 | - | expression tag |
Lys -6 | - | expression tag |
Leu -5 | - | expression tag |
Ala -4 | - | expression tag |
Gly -3 | - | expression tag |
Gly -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Ser 68 | Cys 68 | conflict |
PDB | External Database | Details |
---|---|---|
Met -92 | - | initiating methionine |
Lys -91 | - | expression tag |
Thr -90 | - | expression tag |
Ile -89 | - | expression tag |
Ile -88 | - | expression tag |
Ala -87 | - | expression tag |
Leu -86 | - | expression tag |
Ser -85 | - | expression tag |
Tyr -84 | - | expression tag |
Ile -83 | - | expression tag |
Phe -82 | - | expression tag |
Cys -81 | - | expression tag |
Leu -80 | - | expression tag |
Val -79 | - | expression tag |
Phe -78 | - | expression tag |
Ala -77 | - | expression tag |
Asp -76 | - | expression tag |
Tyr -75 | - | expression tag |
Lys -74 | - | expression tag |
Asp -73 | - | expression tag |
Asp -72 | - | expression tag |
Asp -71 | - | expression tag |
Asp -70 | - | expression tag |
Ala -69 | - | expression tag |
Lys -68 | - | expression tag |
Leu -67 | - | expression tag |
Gln -66 | - | expression tag |
Thr -65 | - | expression tag |
Met -64 | - | expression tag |
His -63 | - | expression tag |
His -62 | - | expression tag |
His -61 | - | expression tag |
His -60 | - | expression tag |
His -59 | - | expression tag |
His -58 | - | expression tag |
His -57 | - | expression tag |
His -56 | - | expression tag |
His -55 | - | expression tag |
His -54 | - | expression tag |
Glu -53 | - | expression tag |
Asn -52 | - | expression tag |
Leu -51 | - | expression tag |
Tyr -50 | - | expression tag |
Phe -49 | - | expression tag |
Gln -48 | - | expression tag |
Gly -47 | - | expression tag |
Gly -46 | - | expression tag |
Gly -45 | - | expression tag |
Arg -44 | - | expression tag |
Trp -37 | Met 29 | conflict |
Ile 58 | His 124 | conflict |
Leu 62 | - | linker |
Leu 63 | - | linker |
Glu 64 | - | linker |
Val 65 | - | linker |
Leu 66 | - | linker |
Phe 67 | - | linker |
Gln 68 | - | linker |
Gly 69 | - | linker |
Pro 70 | - | linker |
PDB | External Database | Details |
---|---|---|
Ile 210 | Thr 210 | conflict |
Lys 273 | Glu 273 | conflict |
Val 283 | Thr 283 | conflict |
Glu 340 | Arg 340 | conflict |
His 426 | - | expression tag |
His 427 | - | expression tag |
His 428 | - | expression tag |
His 429 | - | expression tag |
His 430 | - | expression tag |
His 431 | - | expression tag |
His 432 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 153524.7 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 360.8 | |
All* | Total formula weight | 153885.6 |