8K7L
Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3R,4S,5R)-2-(aminomethyl)-5-(hydroxymethyl)-1-methylpyrrolidine-3,4-diol
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Alpha-galactosidase A | polymer | 398 | 45394.5 | 2 | UniProt (P06280) Pfam (PF16499) Pfam (PF17450) In PDB | Homo sapiens (human) | Alpha-D-galactosidase A,Alpha-D-galactoside galactohydrolase,Galactosylgalactosylglucosylceramidase GLA,Melibiase |
2 | C, F | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G81315DD) | |||
3 | D, E | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
4 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
5 | A, B | (2~{R},3~{R},4~{S},5~{R})-2-(aminomethyl)-5-(hydroxymethyl)-1-methyl-pyrrolidine-3,4-diol | non-polymer | 176.2 | 2 | Chemie (VO0) | |||
6 | A, B | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
7 | B | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
8 | water | water | 18.0 | 768 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 90789.1 | |
Branched | Number of molecules | 4 |
Total formula weight | 2346.2 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 1367.3 | |
All* | Total formula weight | 94502.5 |