8K7I

Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3S,4R,5R)-2-(hydroxymethyl)-5-((methylamino)methyl)pyrrolidine-3,4-diol

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Alpha-galactosidase A	polymer	398	45394.5	2	UniProt (P06280) Pfam (PF16499) Pfam (PF17450) In PDB	Homo sapiens (human)	Alpha-D-galactosidase A,Alpha-D-galactoside galactohydrolase,Galactosylgalactosylglucosylceramidase GLA,Melibiase
2	C, F	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	2	In PDB GlyTouCan (G81315DD)
3	D, E	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
4	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
5	A, B	(2~{R},3~{S},4~{R},5~{R})-2-(hydroxymethyl)-5-(methylaminomethyl)pyrrolidine-3,4-diol	non-polymer		176.2	2	Chemie (VN0)
6	A, B	SULFATE ION	non-polymer		96.1	5	Chemie (SO4)
7	A	HEXAETHYLENE GLYCOL	non-polymer		282.3	1	Chemie (P6G)
8	A, B	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
9		water	water		18.0	724	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	90789.1
Branched	Number of molecules	4
	Total formula weight	2346.2
Non-Polymers*	Number of molecules	12
	Total formula weight	1741.7
All*	Total formula weight	94876.9

*Water molecules are not included.