8K7E

Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3R,4S,5R)-2-(aminomethyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Alpha-galactosidase A	polymer	398	45394.5	2	UniProt (P06280) Pfam (PF16499) Pfam (PF17450)	Homo sapiens (human)	Alpha-D-galactosidase A,Alpha-D-galactoside galactohydrolase,Galactosylgalactosylglucosylceramidase GLA,Melibiase
2	C, D (C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
3	E (E)	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G81315DD)
4	F, I (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
5	G, J (A, B)	(2~{R},3~{R},4~{S},5~{R})-2-(aminomethyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol	non-polymer		162.2	2	Chemie (VLN) PubChem (46189542) PubChem (56926969) PubChem (56926971) PubChem (56926973) PubChem (68012337) PubChem (72789564) PubChem (91620972) PubChem (11298136) PubChem (11446508) PubChem (12103482) PubChem (12103488) PubChem (102029943) PubChem (102029945) PubChem (102505367) PubChem (130818537) PubChem (130940888) PubChem (131002287) PubChem (131018771) PubChem (163806620)
6	H, K (A, B)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
7	L, M (A, B)	water	water		18.0	550	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	90789.1
Branched	Number of molecules	3
	Total formula weight	1597.5
Non-Polymers*	Number of molecules	6
	Total formula weight	958.9
All*	Total formula weight	93345.5

*Water molecules are not included.