8K77
Cryo-EM structure of SV2A in complex with BoNT/A2 Hc and brivaracetam
This is a non-PDB format compatible entry.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Synaptic vesicle glycoprotein 2A | polymer | 750 | 83774.0 | 1 | UniProt (Q7L0J3) Pfam (PF00083) Pfam (PF07690) In PDB | Homo sapiens (human) | |
2 | B | Botulinum neurotoxin | polymer | 426 | 49456.2 | 1 | UniProt (D2KCK3) Pfam (PF07953) Pfam (PF07951) In PDB | Clostridium botulinum | |
3 | C | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
4 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
5 | A | (2S)-2-[(4R)-2-oxidanylidene-4-propyl-pyrrolidin-1-yl]butanamide | non-polymer | 212.3 | 1 | Chemie (VLX) |
Sequence modifications
A: 2 - 742 (UniProt: Q7L0J3)
PDB | External Database | Details |
---|---|---|
Met -7 | - | initiating methionine |
Asp -6 | - | expression tag |
Tyr -5 | - | expression tag |
Lys -4 | - | expression tag |
Asp -3 | - | expression tag |
Asp -2 | - | expression tag |
Asp -1 | - | expression tag |
Asp 0 | - | expression tag |
Lys 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 133230.2 | |
Branched | Number of molecules | 1 |
Total formula weight | 570.5 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 654.7 | |
All* | Total formula weight | 134455.4 |