8K6M

Structural complex of neuropeptide Y receptor 1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Guanine nucleotide-binding protein G(i) subunit alpha-2	polymer	355	40516.9	1	UniProt (P04899) Pfam (PF00503) In PDB	Homo sapiens (human)	Adenylate cyclase-inhibiting G alpha protein
2	B	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	356	39141.8	1	UniProt (P62873) Pfam (PF00400) In PDB	Homo sapiens (human)	Transducin beta chain 1
3	C	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7861.1	1	UniProt (P59768) Pfam (PF00631) In PDB	Homo sapiens (human)	G gamma-I
4	D	Neuropeptide Y receptor type 1	polymer	349	40569.4	1	UniProt (P25929) Pfam (PF00001) In PDB	Homo sapiens (human)	NPY1-R
5	S	scFV16	polymer	266	28636.8	1		Mus musculus
6	E	Neuropeptide Y	polymer	36	4278.7	1	UniProt (P01303) Pfam (PF00159) In PDB	Homo sapiens	CPON,C-flanking peptide of NPY

Sequence modifications

A: 1 - 355 (UniProt: P04899)

PDB	External Database	Details
Leu 5	Val 5	variant
Asn 47	Ser 47	engineered mutation
Ala 204	Gly 204	engineered mutation
Ala 246	Glu 246	engineered mutation
Ser 327	Ala 327	engineered mutation

B: 2 - 340 (UniProt: P62873)

PDB	External Database	Details
Met -15	-	initiating methionine
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Leu -10	-	expression tag
Glu -9	-	expression tag
Val -8	-	expression tag
Leu -7	-	expression tag
Phe -6	-	expression tag
Gln -5	-	expression tag
Gly -4	-	expression tag
Pro -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Ser 0	-	expression tag
Gly 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	161004.8
All*	Total formula weight	161004.8

*Water molecules are not included.