8K3S

Structure of PKD2-F604P complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Polycystin-2	polymer	571	66029.8	4	UniProt (Q13563) Pfam (PF20519) Pfam (PF08016)	Homo sapiens (human)	PC2,Autosomal dominant polycystic kidney disease type II protein,Polycystic kidney disease 2 protein,Polycystwin,R48321,Transient receptor potential cation channel subfamily P member 2
2	E, J, N, R (A, B, C, D)	DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE	non-polymer		692.0	4	Chemie (PEF)
3	F, G, H, K, L... (A, B, C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	12	Chemie (NAG)
4	I (A)	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)

Sequence modifications

A, B, C, D: 185 - 719 (UniProt: Q13563)

PDB	External Database	Details
Met 149	-	initiating methionine
Ser 150	-	expression tag
Ala 151	-	expression tag
Trp 152	-	expression tag
Ser 153	-	expression tag
His 154	-	expression tag
Pro 155	-	expression tag
Gln 156	-	expression tag
Phe 157	-	expression tag
Glu 158	-	expression tag
Lys 159	-	expression tag
Gly 160	-	expression tag
Gly 161	-	expression tag
Gly 162	-	expression tag
Ser 163	-	expression tag
Gly 164	-	expression tag
Gly 165	-	expression tag
Gly 166	-	expression tag
Ser 167	-	expression tag
Gly 168	-	expression tag
Gly 169	-	expression tag
Ser 170	-	expression tag
Ala 171	-	expression tag
Trp 172	-	expression tag
Ser 173	-	expression tag
His 174	-	expression tag
Pro 175	-	expression tag
Gln 176	-	expression tag
Phe 177	-	expression tag
Glu 178	-	expression tag
Lys 179	-	expression tag
Gly 180	-	expression tag
Ser 181	-	expression tag
Ala 182	-	expression tag
Ala 183	-	expression tag
Ala 184	-	expression tag
Pro 604	Phe 604	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	264119.3
Non-Polymers*	Number of molecules	17
	Total formula weight	5462.4
All*	Total formula weight	269581.7

*Water molecules are not included.