8JVI

Structure of human TRPV4 with antagonist A2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (B, C, D, A)	Transient receptor potential cation channel subfamily V member 4,3C-GFP	polymer	1144	128628.5	4	UniProt (Q9HBA0) Pfam (PF00023) Pfam (PF00520)	Homo sapiens (human)	TrpV4,Osm-9-like TRP channel 4,OTRPC4,Transient receptor potential protein 12,TRP12,Vanilloid receptor-like channel 2,Vanilloid receptor-like protein 2,VRL-2,Vanilloid receptor-related osmotically-activated channel,VR-OAC
2	E, F, G, H (B, C, D, A)	[6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[(1~{S},5~{R})-3-[5-(trifluoromethyl)pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone	non-polymer		572.6	4	Chemie (F9M)

Sequence modifications

B, C, D, A: 1 - 871 (UniProt: Q9HBA0)
B, C, D, A: 872 - 1144 (PDB: 8JVI)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	514514.2
Non-Polymers*	Number of molecules	4
	Total formula weight	2290.5
All*	Total formula weight	516804.7

*Water molecules are not included.