8JUX
Crystal structure of SARS-CoV-2 Papain-like protease complexed with noncovalent inhibitor SR-01
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Non-structural protein 7 | polymer | 317 | 35851.7 | 2 | UniProt (P0DTD1) Pfam (PF08715) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2) | nsp7,Papain-like protease |
| 2 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 3 | D, E (A, B) | ~{N}-[(3-fluorophenyl)methyl]-1-[(1~{R})-1-(3-methoxynaphthalen-1-yl)ethyl]piperidine-4-carboxamide | non-polymer | 420.5 | 2 | Chemie (V00) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 7 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 317 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Ser 111 | Cys 1674 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 71703.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 865.3 | |
| All* | Total formula weight | 72568.7 |
