8JUE

Crystal structure of glutaminase C in complex with compound 11

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Glutaminase kidney isoform, mitochondrial	polymer	533	58780.9	4	UniProt (O94925) Pfam (PF17959) Pfam (PF04960) In PDB	Homo sapiens (human)	GLS,K-glutaminase,L-glutamine amidohydrolase
2	B, C	2-(3-phenoxyphenyl)-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]ethanamide	non-polymer		473.6	2	Chemie (V59)
3		water	water		18.0	360	Chemie (HOH)

Sequence modifications

A, B, C, D: 71 - 595 (UniProt: O94925)

PDB	External Database	Details
Met 63	-	initiating methionine
Gly 64	-	expression tag
His 65	-	expression tag
His 66	-	expression tag
His 67	-	expression tag
His 68	-	expression tag
His 69	-	expression tag
His 70	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	235123.4
Non-Polymers*	Number of molecules	2
	Total formula weight	947.1
All*	Total formula weight	236070.5

*Water molecules are not included.