8JS8
Cryo-EM structure of SV2A in complex with BoNT/A2 Hc and levetiracetam
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Synaptic vesicle glycoprotein 2A | polymer | 750 | 83774.0 | 1 | UniProt (Q7L0J3) Pfam (PF00083) Pfam (PF07690) | Homo sapiens (human) | |
| 2 | B (B) | Botulinum neurotoxin | polymer | 426 | 49456.2 | 1 | UniProt (D2KCK3) Pfam (PF07953) Pfam (PF07951) UniProt (by SIFTS) (Q45894) | Clostridium botulinum | |
| 3 | C (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 4 | D, E (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 5 | F (A) | (2S)-2-(2-oxidanylidenepyrrolidin-1-yl)butanamide | non-polymer | 170.2 | 1 | Chemie (UKX) |
Sequence modifications
A: 2 - 742 (UniProt: Q7L0J3)
| PDB | External Database | Details |
|---|---|---|
| Met -7 | - | initiating methionine |
| Asp -6 | - | expression tag |
| Tyr -5 | - | expression tag |
| Lys -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Asp 0 | - | expression tag |
| Lys 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 133230.2 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 570.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 612.6 | |
| All* | Total formula weight | 134413.4 |
