8JRQ

Structure of E6AP-E6 complex in Det1 state

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (B, D)	Protein E6	polymer	158	19157.1	2	UniProt (P03126) Pfam (PF00518)	Human papillomavirus 16
2	B, D (A, C)	Ubiquitin-protein ligase E3A	polymer	875	100779.4	2	UniProt (Q05086) Pfam (PF16558) Pfam (PF00632)	Homo sapiens (human)	E6AP ubiquitin-protein ligase,HECT-type ubiquitin transferase E3A,Human papillomavirus E6-associated protein,Oncogenic protein-associated protein E6-AP,Renal carcinoma antigen NY-REN-54
3	E, F, G, H (B, D)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)

Sequence modifications

B, D: 1 - 158 (UniProt: P03126)

PDB	External Database	Details
Ser 87	Cys 87	engineered mutation
Ser 104	Cys 104	engineered mutation
Ser 118	Cys 118	engineered mutation
Ser 147	Cys 147	engineered mutation

A, C: 1 - 875 (UniProt: Q05086)

PDB	External Database	Details
Ala 843	Cys 843	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	239873.2
Non-Polymers*	Number of molecules	4
	Total formula weight	261.6
All*	Total formula weight	240134.8

*Water molecules are not included.