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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8JPN

Cryo-EM structure of succinate receptor bound to cis-epoxysuccinic acid coupling to Gi

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Guanine nucleotide-binding protein G(i) subunit alpha-1polymer35440415.01UniProt (P63096)
Pfam (PF00503)		Homo sapiens (human)Adenylate cyclase-inhibiting G alpha protein
2B
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer37741055.91UniProt (P62873)
Pfam (PF25391)		Homo sapiens (human)Transducin beta chain 1
3C
(C)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P59768)
Pfam (PF00631)		Homo sapiens (human)G gamma-I
4D
(R)		Soluble cytochrome b562,Succinate receptor 1,Oplophorus-luciferin 2-monooxygenase catalytic subunitpolymer65875122.81UniProt (P0ABE7)
UniProt (Q9BXA5)
UniProt (Q9GV45)
Pfam (PF00001)		Escherichia coliCytochrome b-562,G-protein coupled receptor 91,P2Y purinoceptor 1-like,19kOLase
5E
(S)		scFv16polymer28630668.21Homo sapiens (human)
6F
(R)		(2R,3S)-oxirane-2,3-dicarboxylic acidnon-polymer132.11Chemie (U9S)
Sequence modifications
B: 2 - 340 (UniProt: P62873)
PDBExternal DatabaseDetails
Met -10-initiating methionine
His -9-expression tag
His -8-expression tag
His -7-expression tag
His -6-expression tag
His -5-expression tag
His -4-expression tag
Gly -3-expression tag
Ser -2-expression tag
Leu -1-expression tag
Leu 0-expression tag
Gln 1-expression tag
Gly 341-expression tag
Ser 342-expression tag
Ser 343-expression tag
Gly 344-expression tag
Gly 345-expression tag
Gly 346-expression tag
Gly 347-expression tag
Ser 348-expression tag
Gly 349-expression tag
Gly 350-expression tag
Gly 351-expression tag
Gly 352-expression tag
Ser 353-expression tag
Ser 354-expression tag
Gly 355-expression tag
Val 356-expression tag
Ser 357-expression tag
Gly 358-expression tag
Trp 359-expression tag
Arg 360-expression tag
Leu 361-expression tag
Phe 362-expression tag
Lys 363-expression tag
Lys 364-expression tag
Ile 365-expression tag
Ser 366-expression tag
R: -115 - -11 (UniProt: P0ABE7)
PDBExternal DatabaseDetails
Met -162-initiating methionine
Lys -161-expression tag
Thr -160-expression tag
Ile -159-expression tag
Ile -158-expression tag
Ala -157-expression tag
Leu -156-expression tag
Ser -155-expression tag
Tyr -154-expression tag
Ile -153-expression tag
Phe -152-expression tag
Cys -151-expression tag
Leu -150-expression tag
Val -149-expression tag
Phe -148-expression tag
Ala -147-expression tag
Asp -146-expression tag
Tyr -145-expression tag
Lys -144-expression tag
Asp -143-expression tag
Asp -142-expression tag
Asp -141-expression tag
Asp -140-expression tag
Ala -139-expression tag
Gly -138-expression tag
Arg -137-expression tag
Ala -136-expression tag
His -135-expression tag
His -134-expression tag
His -133-expression tag
His -132-expression tag
His -131-expression tag
His -130-expression tag
His -129-expression tag
His -128-expression tag
His -127-expression tag
His -126-expression tag
Glu -125-expression tag
Asn -124-expression tag
Leu -123-expression tag
Tyr -122-expression tag
Phe -121-expression tag
Gln -120-expression tag
Ser -119-expression tag
Gly -118-expression tag
Ala -117-expression tag
Pro -116-expression tag
Trp -109Met 29conflict
Ile -14His 124conflict
Leu -10-linker
Leu -9-linker
Glu -8-linker
Val -7-linker
Leu -6-linker
Phe -5-linker
Gln -4-linker
Gly -3-linker
Pro -2-linker
Glu -1-linker
Phe 0-linker
R: 1 - 334 (UniProt: Q9BXA5)
PDBExternal DatabaseDetails
Phe 46Tyr 46conflict
Leu 49Ile 49conflict
Cys 51Ser 51conflict
Ile 67Val 67conflict
Tyr 175Phe 175conflict
Leu 221Val 221conflict
Glu 304Asp 304conflict
Lys 309Gln 309conflict
Arg 321Ser 321conflict
Ala 335-linker
Ala 336-linker
Ala 337-linker
Val 338-linker
R: 339 - 495 (UniProt: Q9GV45)
PDBExternal DatabaseDetails
Glu 342Ala 31conflict
Glu 349Gln 38conflict
Ala 353Gly 42conflict
Leu 356Gln 45conflict
Val 365Leu 54conflict
Leu 369Phe 58conflict
Asn 371Ala 60conflict
Ala 373Gly 62conflict
Arg 381Lys 70conflict
Ile 382Val 71conflict
Arg 384Leu 73conflict
Ala 389Gly 78conflict
Ile 392Ala 81conflict
Ala 405Gly 94conflict
Asp 406Phe 95conflict
Ala 409Gly 98conflict
Gln 410Leu 99conflict
Glu 413Met 102conflict
Val 414Ile 103conflict
Val 428Ile 117conflict
Pro 431His 120conflict
Leu 445Ile 134conflict
Asn 446Asp 135conflict
Glu 453Pro 142conflict
Lys 462Gln 151conflict
Ile 476Tyr 165conflict
Thr 482Asn 171conflict
Met 487Leu 176conflict
Ser 495Gly 184conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains5
Total formula weight195123.1
Non-Polymers*Number of molecules1
Total formula weight132.1
All*Total formula weight195255.1
*Water molecules are not included.

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PDB entries from 2026-01-21

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