8JP1

Crystal structure of AKR1C3 in complex with DFV

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Aldo-keto reductase family 1 member C3	polymer	331	37977.4	2	UniProt (P42330) Pfam (PF00248) In PDB	Homo sapiens (human)	17-beta-hydroxysteroid dehydrogenase type 5,17-beta-HSD 5,3-alpha-HSD type II,brain,3-alpha-hydroxysteroid dehydrogenase type 2,3-alpha-HSD type 2,Chlordecone reductase homolog HAKRb,Dihydrodiol dehydrogenase 3,DD-3,DD3,Dihydrodiol dehydrogenase type I,HA1753,Prostaglandin F synthase,PGFS,Testosterone 17-beta-dehydrogenase 5
2	A, B	NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		743.4	2	Chemie (NAP)
3	A, B	7-HYDROXY-2-(4-HYDROXY-PHENYL)-CHROMAN-4-ONE	non-polymer		256.3	2	Chemie (DFV)
4		water	water		18.0	1092	Chemie (HOH)

Sequence modifications

A, B: 1 - 323 (UniProt: P42330)

PDB	External Database	Details
Leu 324	-	expression tag
Glu 325	-	expression tag
His 326	-	expression tag
His 327	-	expression tag
His 328	-	expression tag
His 329	-	expression tag
His 330	-	expression tag
His 331	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	75954.7
Non-Polymers*	Number of molecules	4
	Total formula weight	1999.3
All*	Total formula weight	77954.1

*Water molecules are not included.