8JOK

Crystal structure of V30L mutated human transthyretin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Transthyretin	polymer	136	14953.7	2	UniProt (P02766) Pfam (PF00576) In PDB	Homo sapiens (human)	ATTR,Prealbumin,TBPA
2	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
3		water	water		18.0	144	Chemie (HOH)

Sequence modifications

A, B: 1 - 127 (UniProt: P02766)

PDB	External Database	Details
Met -8	-	initiating methionine
Ala -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
Met 0	-	expression tag
Leu 30	Val 50	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	29907.5
Non-Polymers*	Number of molecules	2
	Total formula weight	48.6
All*	Total formula weight	29956.1

*Water molecules are not included.