8JLQ

Fenoldopam-bound hTAAR1-Gs protein complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	mGs	polymer	371	43117.9	1	Pfam (PF00503) UniProt (by SIFTS) (P63096) UniProt (by SIFTS) (Q5JWF2) UniProt (by SIFTS) (P63092)	Homo sapiens
2	B (B)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	358	39418.1	1	UniProt (P62873) Pfam (PF25391)	Homo sapiens (human)	Transducin beta chain 1
3	C (R)	Soluble cytochrome b562,Trace amine-associated receptor 1	polymer	470	54128.1	1	UniProt (P0ABE7) UniProt (Q96RJ0) Pfam (PF00001)	Escherichia coli	Cytochrome b-562
4	D (S)	ScFv16	polymer	251	26709.7	1		Mus musculus
5	E (Y)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7861.1	1	UniProt (P59768) Pfam (PF00631)	Homo sapiens (human)	G gamma-I
6	F (R)	(1R)-6-chloranyl-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol	non-polymer		305.8	1	Chemie (G3C)

Sequence modifications

B: 2 - 340 (UniProt: P62873)

PDB	External Database	Details
Met -17	-	initiating methionine
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Leu -10	-	expression tag
Glu -9	-	expression tag
Val -8	-	expression tag
Leu -7	-	expression tag
Phe -6	-	expression tag
Gln -5	-	expression tag
Gly -4	-	expression tag
Pro -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Ser 0	-	expression tag
Gly 1	-	expression tag

R: -105 - 0 (UniProt: P0ABE7)

PDB	External Database	Details
Asp -130	-	expression tag
Tyr -129	-	expression tag
Lys -128	-	expression tag
Asp -127	-	expression tag
Asp -126	-	expression tag
Asp -125	-	expression tag
Asp -124	-	expression tag
Lys -123	-	expression tag
His -122	-	expression tag
His -121	-	expression tag
His -120	-	expression tag
His -119	-	expression tag
His -118	-	expression tag
His -117	-	expression tag
His -116	-	expression tag
His -115	-	expression tag
His -114	-	expression tag
His -113	-	expression tag
Glu -112	-	expression tag
Asn -111	-	expression tag
Leu -110	-	expression tag
Tyr -109	-	expression tag
Phe -108	-	expression tag
Gln -107	-	expression tag
Gly -106	-	expression tag
Trp -99	Met 29	engineered mutation
Ile -4	His 124	engineered mutation
Leu 0	Arg 128	engineered mutation

R: 1 - 339 (UniProt: Q96RJ0)

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	171235.0
Non-Polymers*	Number of molecules	1
	Total formula weight	305.8
All*	Total formula weight	171540.8

*Water molecules are not included.