8JLO
Ulotaront(SEP-363856)-bound hTAAR1-Gs protein complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 394 | 45699.4 | 1 | UniProt (P63092) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-stimulating G alpha protein |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 356 | 39141.8 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
3 | R | Soluble cytochrome b562,Trace amine-associated receptor 1 | polymer | 470 | 54128.1 | 1 | UniProt (P0ABE7) UniProt (Q96RJ0) Pfam (PF00001) Pfam (PF07361) In PDB | Escherichia coli | Cytochrome b-562 |
4 | Y | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
5 | R | 1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine | non-polymer | 183.3 | 1 | Chemie (UJL) |
Sequence modifications
A: 1 - 394 (UniProt: P63092)
B: 2 - 340 (UniProt: P62873)
R: -105 - 0 (UniProt: P0ABE7)
R: 1 - 339 (UniProt: Q96RJ0)
PDB | External Database | Details |
---|---|---|
Asn 54 | Ser 54 | variant |
Ala 226 | Gly 226 | variant |
Ala 268 | Glu 268 | variant |
Lys 271 | Asn 271 | variant |
Asp 274 | Lys 274 | variant |
Lys 280 | Arg 280 | variant |
Asp 284 | Thr 284 | variant |
Thr 285 | Ile 285 | variant |
Ser 366 | Ala 366 | variant |
PDB | External Database | Details |
---|---|---|
Met -15 | - | initiating methionine |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
Leu -10 | - | expression tag |
Glu -9 | - | expression tag |
Val -8 | - | expression tag |
Leu -7 | - | expression tag |
Phe -6 | - | expression tag |
Gln -5 | - | expression tag |
Gly -4 | - | expression tag |
Pro -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Asp -130 | - | expression tag |
Tyr -129 | - | expression tag |
Lys -128 | - | expression tag |
Asp -127 | - | expression tag |
Asp -126 | - | expression tag |
Asp -125 | - | expression tag |
Asp -124 | - | expression tag |
Lys -123 | - | expression tag |
His -122 | - | expression tag |
His -121 | - | expression tag |
His -120 | - | expression tag |
His -119 | - | expression tag |
His -118 | - | expression tag |
His -117 | - | expression tag |
His -116 | - | expression tag |
His -115 | - | expression tag |
His -114 | - | expression tag |
His -113 | - | expression tag |
Glu -112 | - | expression tag |
Asn -111 | - | expression tag |
Leu -110 | - | expression tag |
Tyr -109 | - | expression tag |
Phe -108 | - | expression tag |
Gln -107 | - | expression tag |
Gly -106 | - | expression tag |
Trp -99 | Met 29 | engineered mutation |
Ile -4 | His 124 | engineered mutation |
Leu 0 | Arg 128 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 146830.5 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 183.3 | |
All* | Total formula weight | 147013.8 |