8JHZ
Cryo-EM structure of the TcsH-TMPRSS2 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Hemorrhagic toxin | polymer | 2626 | 300675.2 | 1 | UniProt (M9ZTT7) Pfam (PF12918) Pfam (PF19127) Pfam (PF01473) Pfam (PF12919) Pfam (PF11713) Pfam (PF12920) | Paeniclostridium sordellii (Clostridium sordellii) | |
| 2 | B (B) | Transmembrane protease serine 2 | polymer | 424 | 46713.0 | 1 | UniProt (O15393) Pfam (PF15494) Pfam (PF00089) | Homo sapiens (human) | Serine protease 10 |
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
A: 1 - 2618 (UniProt: M9ZTT7)
B: 106 - 492 (UniProt: O15393)
| PDB | External Database | Details |
|---|---|---|
| Ser 1833 | Leu 1833 | conflict |
| His 2619 | - | expression tag |
| His 2620 | - | expression tag |
| His 2621 | - | expression tag |
| His 2622 | - | expression tag |
| His 2623 | - | expression tag |
| His 2624 | - | expression tag |
| His 2625 | - | expression tag |
| His 2626 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 69 | - | initiating methionine |
| Gly 70 | - | expression tag |
| Ile 71 | - | expression tag |
| Leu 72 | - | expression tag |
| Pro 73 | - | expression tag |
| Ser 74 | - | expression tag |
| Pro 75 | - | expression tag |
| Gly 76 | - | expression tag |
| Met 77 | - | expression tag |
| Pro 78 | - | expression tag |
| Ala 79 | - | expression tag |
| Leu 80 | - | expression tag |
| Leu 81 | - | expression tag |
| Ser 82 | - | expression tag |
| Leu 83 | - | expression tag |
| Val 84 | - | expression tag |
| Ser 85 | - | expression tag |
| Leu 86 | - | expression tag |
| Leu 87 | - | expression tag |
| Ser 88 | - | expression tag |
| Val 89 | - | expression tag |
| Leu 90 | - | expression tag |
| Leu 91 | - | expression tag |
| Met 92 | - | expression tag |
| Gly 93 | - | expression tag |
| Cys 94 | - | expression tag |
| Val 95 | - | expression tag |
| Ala 96 | - | expression tag |
| Glu 97 | - | expression tag |
| Thr 98 | - | expression tag |
| Gly 99 | - | expression tag |
| His 100 | - | expression tag |
| His 101 | - | expression tag |
| His 102 | - | expression tag |
| His 103 | - | expression tag |
| His 104 | - | expression tag |
| His 105 | - | expression tag |
| Gln 255 | Arg 255 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 347388.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 65.4 | |
| All* | Total formula weight | 347453.6 |
