8JHI
FZD3-Gs complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas | polymer | 248 | 28861.9 | 1 | UniProt (Q5JWF2) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-stimulating G alpha protein,Extra large alphas protein,XLalphas |
| 2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 337 | 37069.5 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 57 | 6261.2 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
| 4 | N | Nb35 | polymer | 126 | 13711.3 | 1 | Homo sapiens (human) | ||
| 5 | R | Frizzled-3 | polymer | 520 | 60076.3 | 1 | UniProt (Q9NPG1) Pfam (PF01392) Pfam (PF01534) In PDB | Homo sapiens (human) |
Sequence modifications
A: 7 - 195 (UniProt: Q5JWF2)
A: 204 - 394 (UniProt: Q5JWF2)
| PDB | External Database | Details |
|---|---|---|
| Asn 1 | - | expression tag |
| Ser 2 | - | expression tag |
| Lys 3 | - | expression tag |
| Thr 4 | - | expression tag |
| Glu 5 | - | expression tag |
| Asp 6 | - | expression tag |
| Asp 44 | Gly 692 | engineered mutation |
| Asn 45 | Glu 693 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 196 | - | linker |
| Gly 197 | - | linker |
| Ser 198 | - | linker |
| Gly 199 | - | linker |
| Gly 200 | - | linker |
| Ser 201 | - | linker |
| Gly 202 | - | linker |
| Gly 203 | - | linker |
| Asp 249 | Ala 892 | engineered mutation |
| Asp 252 | Ser 895 | engineered mutation |
| - | Asn 897 | deletion |
| - | Met 898 | deletion |
| - | Val 899 | deletion |
| - | Ile 900 | deletion |
| - | Arg 901 | deletion |
| - | Glu 902 | deletion |
| - | Asp 903 | deletion |
| - | Asn 904 | deletion |
| - | Gln 905 | deletion |
| - | Thr 906 | deletion |
| Ala 372 | Ile 1015 | engineered mutation |
| Ile 375 | Val 1018 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 145980.3 | |
| All* | Total formula weight | 145980.3 |
