8JHG

Native SUV420H1 bound to 167-bp nucleosome

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (K)	Histone-lysine N-methyltransferase KMT5B	polymer	361	41330.7	1	UniProt (Q4FZB7) Pfam (PF00856)	Homo sapiens (human)	Lysine N-methyltransferase 5B,Lysine-specific methyltransferase 5B,Suppressor of variegation 4-20 homolog 1,Su(var)4-20 homolog 1,Suv4-20h1,[histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B,[histone H4]-lysine20 N-methyltransferase KMT5B
2	B, F (A, E)	Histone H3.1	polymer	136	15437.2	2	UniProt (P68431) Pfam (PF00125)	Homo sapiens (human)	Histone H3/a,Histone H3/b,Histone H3/c,Histone H3/d,Histone H3/f,Histone H3/h,Histone H3/i,Histone H3/j,Histone H3/k,Histone H3/l
3	C, G (B, F)	Histone H4	polymer	86	9863.6	2	UniProt (P62805) Pfam (PF15511)	Homo sapiens (human)
4	D, H (C, G)	Histone H2A type 1-B/E	polymer	115	12675.8	2	UniProt (P04908) Pfam (PF00125) Pfam (PF16211)	Homo sapiens (human)	Histone H2A.2,Histone H2A/a,Histone H2A/m
5	E, I (D, H)	Histone H2B type 1-K	polymer	95	10607.2	2	UniProt (O60814) Pfam (PF00125)	Homo sapiens (human)	H2B K,HIRA-interacting protein 1
6	J (I)	DNA (160-MER)	polymer	160	49038.2	1		Homo sapiens (human)
7	K (J)	DNA (160-MER)	polymer	160	49745.7	1		Homo sapiens (human)
8	L (K)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
9	M (K)	S-ADENOSYLMETHIONINE	non-polymer		398.4	1	Chemie (SAM)

Sequence modifications

B, F: 17 - 102 (UniProt: P62805)

PDB	External Database	Details
Met 20	Lys 21	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	11
	Total formula weight	237282.1
Non-Polymers*	Number of molecules	2
	Total formula weight	463.8
All*	Total formula weight	237745.9

*Water molecules are not included.