8JH7

FZD6 in inactive state

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (H)	anti-BRIL Fab Heavy chain	polymer	240	25704.6	1		Homo sapiens (human)
2	B (K)	anti-Fab Nanobody	polymer	127	14075.4	1		synthetic construct
3	C (L)	anti-BRIL Fab Light chain	polymer	212	23209.8	1		Homo sapiens (human)
4	D (D)	Frizzled-6,Soluble cytochrome b562	polymer	641	73464.4	1	UniProt (O60353) UniProt (P0ABE7) Pfam (PF01392) Pfam (PF01534)	Homo sapiens (human)	Fz-6,hFz6,Cytochrome b-562

Sequence modifications

D: 18 - 396 (UniProt: O60353)

PDB	External Database	Details
Met -22	-	initiating methionine
Lys -21	-	expression tag
Thr -20	-	expression tag
Ile -19	-	expression tag
Ile -18	-	expression tag
Ala -17	-	expression tag
Leu -16	-	expression tag
Ser -15	-	expression tag
Tyr -14	-	expression tag
Ile -13	-	expression tag
Phe -12	-	expression tag
Cys -11	-	expression tag
Leu -10	-	expression tag
Val -9	-	expression tag
Phe -8	-	expression tag
Ala -7	-	expression tag
Asp -6	-	expression tag
Tyr -5	-	expression tag
Lys -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Asp -1	-	expression tag
Asp 0	-	expression tag
Lys 1	-	expression tag
His 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
His 11	-	expression tag
Glu 12	-	expression tag
Asn 13	-	expression tag
Leu 14	-	expression tag
Tyr 15	-	expression tag
Phe 16	-	expression tag
Gln 17	-	expression tag

D: 1006 - 1110 (UniProt: P0ABE7)

PDB	External Database	Details
Trp 1012	Met 29	conflict
Ile 1107	His 124	conflict
Leu 1111	-	linker
Glu 1112	-	linker
Arg 1113	-	linker
Ala 1114	-	linker
Arg 1115	-	linker
Ser 1116	-	linker
Thr 1117	-	linker
Leu 1118	-	linker
Glu	-	linker

D: 408 - 510 (UniProt: O60353)

PDB	External Database	Details
Ala 1001	-	linker
Arg 1002	-	linker
Arg 1003	-	linker
Gln 1004	-	linker
Leu 1005	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	136454.2
All*	Total formula weight	136454.2

*Water molecules are not included.