8JGF
CryoEM structure of Gq-coupled MRGPRX1 with peptide agonist BAM8-22
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein Gq | polymer | 361 | 41724.4 | 1 | Homo sapiens (human) | ||
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 352 | 38561.2 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | |
3 | E | Single-Chain Fragment Variable 16 | polymer | 285 | 30363.0 | 1 | Homo sapiens (human) | ||
4 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 58 | 6375.3 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
5 | L | BAM8-22 | polymer | 15 | 1974.2 | 1 | UniProt (by SIFTS) (P01210) In PDB | Homo sapiens | |
6 | R | Mas-related G-protein coupled receptor member X1 | polymer | 319 | 35906.5 | 1 | UniProt (Q96LB2) Pfam (PF00001) In PDB | Homo sapiens (human) | Sensory neuron-specific G-protein coupled receptor 3/4 |
Sequence modifications
B: 7 - 345 (UniProt: P62873)
PDB | External Database | Details |
---|---|---|
Leu -6 | - | expression tag |
Glu -5 | - | expression tag |
Val -4 | - | expression tag |
Leu -3 | - | expression tag |
Phe -2 | - | expression tag |
Gln -1 | - | expression tag |
Gly 0 | - | expression tag |
Pro 1 | - | expression tag |
Cys 2 | - | expression tag |
Gly 3 | - | expression tag |
Ser 4 | - | expression tag |
Ser 5 | - | expression tag |
Gly 6 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 154904.6 | |
All* | Total formula weight | 154904.6 |