8JGD
GDP-bound KRAS G12C in complex with YK-8S
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A (A) | GTPase KRas | polymer | 169 | 19468.1 | 1 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
2 | B (A) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
4 | D (A) | (2~{S})-1-[4-[7-(8-ethynyl-7-fluoranyl-naphthalen-1-yl)-8-fluoranyl-2-[[(2~{R},8~{S})-2-fluoranyl-1,2,3,5,6,7-hexahydropyrrolizin-8-yl]methoxy]pyrido[4,3-d]pyrimidin-4-yl]piperazin-1-yl]-2-oxidanyl-propan-1-one | non-polymer | 630.7 | 1 | Chemie (DWI) | |||
5 | E (A) | water | water | 18.0 | 258 | Chemie (HOH) |
Sequence modifications
A: 1 - 169 (UniProt: P01116)
PDB | External Database | Details |
---|---|---|
Cys 12 | Gly 12 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 19468.1 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 1098.2 | |
All* | Total formula weight | 20566.2 |