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8JGD

GDP-bound KRAS G12C in complex with YK-8S

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
GTPase KRaspolymer16919468.11UniProt (P01116)
Pfam (PF00071)
Homo sapiens (human)K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras
2B
(A)
GUANOSINE-5'-DIPHOSPHATEnon-polymer443.21Chemie (GDP)
3C
(A)
MAGNESIUM IONnon-polymer24.31Chemie (MG)
4D
(A)
(2~{S})-1-[4-[7-(8-ethynyl-7-fluoranyl-naphthalen-1-yl)-8-fluoranyl-2-[[(2~{R},8~{S})-2-fluoranyl-1,2,3,5,6,7-hexahydropyrrolizin-8-yl]methoxy]pyrido[4,3-d]pyrimidin-4-yl]piperazin-1-yl]-2-oxidanyl-propan-1-onenon-polymer630.71Chemie (DWI)
5E
(A)
waterwater18.0258Chemie (HOH)
Sequence modifications
A: 1 - 169 (UniProt: P01116)
PDBExternal DatabaseDetails
Cys 12Gly 12engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight19468.1
Non-Polymers*Number of molecules3
Total formula weight1098.2
All*Total formula weight20566.2
*Water molecules are not included.

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PDB entries from 2024-10-30

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