8JFH
Crystal structure of 3-oxoacyl-ACP reductase FabG in complex with NADP+ and 3-keto-octanoyl-ACP from Helicobacter pylori in an inactive form that priors the acyl substrate delivery
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | 3-oxoacyl-[acyl-carrier-protein] reductase | polymer | 248 | 26768.5 | 4 | UniProt (G2M827) | Helicobacter pylori | |
| 2 | E, F (E, F) | Acyl carrier protein | polymer | 84 | 9205.4 | 2 | UniProt (Q5EDC8) Pfam (PF00550) | Helicobacter pylori | |
| 3 | G, H, I (A, B, D) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 3 | Chemie (NAP) | |||
| 4 | J (E) | ~{S}-[2-[3-[[(2~{S})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] 3-oxidanylideneoctanethioate | non-polymer | 498.5 | 1 | Chemie (UHC) | |||
| 5 | K (F) | N~3~-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-(2-sulfanylethyl)-beta-alaninamide | non-polymer | 358.3 | 1 | Chemie (PN7) | |||
| 6 | L, M, N, O, P... (A, B, C, D, E...) | water | water | 18.0 | 1163 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 247 (UniProt: G2M827)
E, F: 1 - 78 (UniProt: Q5EDC8)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser -5 | - | expression tag |
| Ser -4 | - | expression tag |
| Met -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Tyr -1 | - | expression tag |
| Leu 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 125484.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 3087.1 | |
| All* | Total formula weight | 128572.0 |
