8JED

Crystal structure of mRNA cap (guanine-N7) methyltransferase E12 subunit from monkeypox virus and discovery of its inhibitors

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	mRNA-capping enzyme regulatory subunit OPG124	polymer	296	34663.9	1	UniProt (A0A7H0DN96) Pfam (PF03341)	Monkeypox virus	Virus termination factor small subunit,mRNA-capping enzyme 33 kDa subunit,mRNA-capping enzyme D12 subunit,mRNA-capping enzyme small subunit
2	B (B)	water	water		18.0	178	Chemie (HOH)

Sequence modifications

B: 1 - 287 (UniProt: A0A7H0DN96)

PDB	External Database	Details
Gly 0	-	expression tag
Thr 93	Ser 93	conflict
Thr 242	Ile 242	conflict
His 288	-	expression tag
His 289	-	expression tag
His 290	-	expression tag
His 291	-	expression tag
His 292	-	expression tag
His 293	-	expression tag
His 294	-	expression tag
His 295	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	34663.9
All*	Total formula weight	34663.9

*Water molecules are not included.