8JE7
Crystal Structure of Anopheles culicifacies Prolyl-tRNA Synthetase (AcPRS) in complex with two inhibitors (Halofuginone and L95)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | PROLYL-TRNA SYNTHETASE | polymer | 505 | 58101.0 | 2 | UniProt (A0A182M1F8) Pfam (PF00587) Pfam (PF03129) Pfam (PF09180) | Anopheles culicifacies | |
| 2 | C, K (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, L (A, B) | 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one | non-polymer | 414.7 | 2 | Chemie (HFG) | |||
| 4 | E, M (A, B) | ~{N}-[4-[(3~{S})-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-6-methyl-pyridin-2-yl]-2-phenyl-ethanamide | non-polymer | 374.4 | 2 | Chemie (JE6) | |||
| 5 | F, G, N, O (A, B) | BROMIDE ION | non-polymer | 79.9 | 4 | Chemie (BR) | |||
| 6 | H, I, P, Q (A, B) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 7 | J, R, S (A, B) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 8 | T, U (A, B) | water | water | 18.0 | 344 | Chemie (HOH) |
Sequence modifications
A, B: 1219 - 1722 (UniProt: A0A182M1F8)
| PDB | External Database | Details |
|---|---|---|
| Met 1218 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 116202.0 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 2503.4 | |
| All* | Total formula weight | 118705.4 |
