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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8JD1

Cryo-EM structure of mGlu2-mGlu3 heterodimer in Rco state

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(2)		Metabotropic glutamate receptor 2,Peptidyl-prolyl cis-trans isomerase FKBP1Apolymer993109398.91UniProt (Q14416)
UniProt (P62942)
Pfam (PF01094)
Pfam (PF07562)
Pfam (PF00003)
Pfam (PF00254)		Homo sapiens (human)mGluR2,PPIase FKBP1A,12 kDa FK506-binding protein,12 kDa FKBP,FKBP-12,Calstabin-1,FK506-binding protein 1A,FKBP-1A,Immunophilin FKBP12,Rotamase
2B
(3)		Metabotropic glutamate receptor 3,Serine/threonine-protein kinase mTORpolymer993112713.01UniProt (Q14832)
UniProt (A0A8V8TRG9)
Pfam (PF01094)
Pfam (PF07562)
Pfam (PF00003)
Pfam (PF08771)		Homo sapiens (human)mGluR3
3C, D
(2, 3)		GLUTAMIC ACIDnon-polymer147.12Chemie (GLU)
PubChem (611)
PubChem (23327)
PubChem (33032)
4E, F, G, H, I...
(3)		CHOLESTEROLnon-polymer386.77Chemie (CLR)
PubChem (16219173)
PubChem (16758052)
PubChem (304)
PubChem (176980071)
PubChem (191463)
PubChem (368063)
PubChem (369319)
PubChem (18640088)
PubChem (1715243)
PubChem (40477506)
PubChem (40557614)
PubChem (42579431)
PubChem (42579432)
PubChem (1715244)
PubChem (23423981)
PubChem (45044259)
PubChem (638019)
PubChem (49853509)
PubChem (50990013)
PubChem (44654663)
PubChem (52934537)
PubChem (56621683)
PubChem (1549081)
PubChem (1553803)
PubChem (46937002)
PubChem (57915018)
PubChem (57939063)
PubChem (58428240)
PubChem (58445498)
PubChem (58663286)
PubChem (59450329)
PubChem (59628412)
PubChem (59965215)
PubChem (71234641)
PubChem (59993755)
PubChem (60001463)
PubChem (66634651)
PubChem (59274407)
PubChem (5283629)
PubChem (5284644)
PubChem (68055877)
PubChem (68166463)
PubChem (68315613)
PubChem (5315842)
PubChem (70795838)
PubChem (70797612)
PubChem (70954610)
PubChem (70957185)
PubChem (71463909)
PubChem (68311425)
PubChem (68311398)
PubChem (143173313)
PubChem (177156123)
PubChem (6419195)
PubChem (5997)
PubChem (6994560)
PubChem (7055705)
PubChem (7055706)
PubChem (7059398)
PubChem (7059400)
PubChem (7059635)
PubChem (7103033)
PubChem (7182477)
PubChem (7182478)
PubChem (89951918)
PubChem (90224410)
PubChem (91298236)
PubChem (9909206)
PubChem (10045721)
PubChem (71168115)
PubChem (10134774)
PubChem (10293553)
PubChem (71173031)
PubChem (11003580)
PubChem (11025495)
PubChem (11058155)
PubChem (11463329)
PubChem (1551269)
PubChem (90070115)
PubChem (11868624)
PubChem (11868625)
PubChem (11869366)
PubChem (11869367)
PubChem (11869368)
PubChem (11869369)
PubChem (12120344)
PubChem (12156156)
PubChem (12303135)
PubChem (12303148)
PubChem (12303156)
PubChem (12303159)
PubChem (12303160)
PubChem (117965027)
PubChem (6432564)
PubChem (101624109)
PubChem (6710666)
PubChem (124146240)
PubChem (7059399)
PubChem (124897607)
PubChem (124896959)
PubChem (10861996)
PubChem (132837164)
PubChem (11834483)
PubChem (11888915)
PubChem (11888914)
PubChem (124225449)
PubChem (124429284)
PubChem (124909223)
PubChem (124909224)
PubChem (124909225)
PubChem (138967089)
PubChem (139566851)
PubChem (130459183)
PubChem (131992107)
PubChem (15939944)
PubChem (139568882)
PubChem (142983773)
PubChem (144054483)
PubChem (144209461)
PubChem (144331236)
PubChem (144808354)
PubChem (145053568)
PubChem (145157652)
PubChem (145215073)
PubChem (145230478)
PubChem (146320991)
PubChem (147857230)
PubChem (154993519)
PubChem (171828367)
PubChem (173516975)
PubChem (158603858)
PubChem (162906452)
PubChem (162906453)
PubChem (162906454)
PubChem (162906455)
PubChem (162906456)
PubChem (162906457)
PubChem (163255768)
PubChem (163389210)
PubChem (164665303)
PubChem (166553771)
PubChem (166712004)
PubChem (170116175)
PubChem (171764280)
PubChem (171817101)
PubChem (171817104)
PubChem (174285573)
Sequence modifications
2: 19 - 872 (UniProt: Q14416)
PDBExternal DatabaseDetails
Asp 9-expression tag
Tyr 10-expression tag
Lys 11-expression tag
Asp 12-expression tag
Asp 13-expression tag
Asp 14-expression tag
Asp 15-expression tag
Gly 16-expression tag
Ala 17-expression tag
Pro 18-expression tag
Leu 873-linker
Glu 874-linker
Val 875-linker
Leu 876-linker
Phe 877-linker
Gln 878-linker
Gly 879-linker
Pro 880-linker
2: 881 - 987 (UniProt: P62942)
PDBExternal DatabaseDetails
Phe 988-expression tag
Ala 989-expression tag
Ala 990-expression tag
Ala 991-expression tag
His 992-expression tag
His 993-expression tag
His 994-expression tag
His 995-expression tag
His 996-expression tag
His 997-expression tag
His 998-expression tag
His 999-expression tag
His 1000-expression tag
His 1001-expression tag
3: 23 - 879 (UniProt: Q14832)
PDBExternal DatabaseDetails
Asp -8-expression tag
Tyr -7-expression tag
Lys -6-expression tag
Asp -5-expression tag
Asp -4-expression tag
Asp -3-expression tag
Asp -2-expression tag
Lys -1-expression tag
Gly 0-expression tag
Ala 1-expression tag
Pro 2-expression tag
Trp 3-expression tag
Ser 4-expression tag
His 5-expression tag
Pro 6-expression tag
Gln 7-expression tag
Phe 8-expression tag
Glu 9-expression tag
Lys 10-expression tag
Gly 11-expression tag
Ser 12-expression tag
Gly 13-expression tag
Ser 14-expression tag
Trp 15-expression tag
Ser 16-expression tag
His 17-expression tag
Pro 18-expression tag
Gln 19-expression tag
Phe 20-expression tag
Glu 21-expression tag
Lys 22-expression tag
Leu 880-linker
Glu 881-linker
Val 882-linker
Leu 883-linker
Phe 884-linker
Gln 885-linker
Gly 886-linker
Pro 887-linker
3: 888 - 982 (UniProt: A0A8V8TRG9)
PDBExternal DatabaseDetails
Glu 983-expression tag
Phe 984-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight222111.9
Non-Polymers*Number of molecules9
Total formula weight3000.8
All*Total formula weight225112.7
*Water molecules are not included.

251422

PDB entries from 2026-04-01

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