8JCW
Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495 and NAM563 (dimerization mode I)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | 2 | Metabotropic glutamate receptor 2,Peptidyl-prolyl cis-trans isomerase FKBP1A | polymer | 993 | 109398.9 | 1 | UniProt (Q14416) UniProt (P62942) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003) Pfam (PF00254) In PDB | Homo sapiens (human) | mGluR2,PPIase FKBP1A,12 kDa FK506-binding protein,12 kDa FKBP,FKBP-12,Calstabin-1,FK506-binding protein 1A,FKBP-1A,Immunophilin FKBP12,Rotamase |
2 | 3 | Metabotropic glutamate receptor 3,Serine/threonine-protein kinase mTOR | polymer | 993 | 112713.0 | 1 | UniProt (Q14832) UniProt (A0A8V8TRG9) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003) Pfam (PF08771) In PDB | Homo sapiens (human) | mGluR3 |
3 | 2, 3 | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
4 | 2, 3 | 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine | non-polymer | 353.4 | 2 | Chemie (Z99) | |||
5 | 2, 3 | CHOLESTEROL | non-polymer | 386.7 | 2 | Chemie (CLR) |
Sequence modifications
2: 19 - 872 (UniProt: Q14416)
2: 881 - 987 (UniProt: P62942)
3: 23 - 879 (UniProt: Q14832)
3: 888 - 982 (UniProt: A0A8V8TRG9)
PDB | External Database | Details |
---|---|---|
Asp 9 | - | expression tag |
Tyr 10 | - | expression tag |
Lys 11 | - | expression tag |
Asp 12 | - | expression tag |
Asp 13 | - | expression tag |
Asp 14 | - | expression tag |
Asp 15 | - | expression tag |
Gly 16 | - | expression tag |
Ala 17 | - | expression tag |
Pro 18 | - | expression tag |
Leu 873 | - | linker |
Glu 874 | - | linker |
Val 875 | - | linker |
Leu 876 | - | linker |
Phe 877 | - | linker |
Gln 878 | - | linker |
Gly 879 | - | linker |
Pro 880 | - | linker |
PDB | External Database | Details |
---|---|---|
Phe 988 | - | expression tag |
Ala 989 | - | expression tag |
Ala 990 | - | expression tag |
Ala 991 | - | expression tag |
His 992 | - | expression tag |
His 993 | - | expression tag |
His 994 | - | expression tag |
His 995 | - | expression tag |
His 996 | - | expression tag |
His 997 | - | expression tag |
His 998 | - | expression tag |
His 999 | - | expression tag |
His 1000 | - | expression tag |
His 1001 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Asp -8 | - | expression tag |
Tyr -7 | - | expression tag |
Lys -6 | - | expression tag |
Asp -5 | - | expression tag |
Asp -4 | - | expression tag |
Asp -3 | - | expression tag |
Asp -2 | - | expression tag |
Lys -1 | - | expression tag |
Gly 0 | - | expression tag |
Ala 1 | - | expression tag |
Pro 2 | - | expression tag |
Trp 3 | - | expression tag |
Ser 4 | - | expression tag |
His 5 | - | expression tag |
Pro 6 | - | expression tag |
Gln 7 | - | expression tag |
Phe 8 | - | expression tag |
Glu 9 | - | expression tag |
Lys 10 | - | expression tag |
Gly 11 | - | expression tag |
Ser 12 | - | expression tag |
Gly 13 | - | expression tag |
Ser 14 | - | expression tag |
Trp 15 | - | expression tag |
Ser 16 | - | expression tag |
His 17 | - | expression tag |
Pro 18 | - | expression tag |
Gln 19 | - | expression tag |
Phe 20 | - | expression tag |
Glu 21 | - | expression tag |
Lys 22 | - | expression tag |
Leu 880 | - | linker |
Glu 881 | - | linker |
Val 882 | - | linker |
Leu 883 | - | linker |
Phe 884 | - | linker |
Gln 885 | - | linker |
Gly 886 | - | linker |
Pro 887 | - | linker |
PDB | External Database | Details |
---|---|---|
Glu 983 | - | expression tag |
Phe 984 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 222111.9 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1922.5 | |
All* | Total formula weight | 224034.3 |