8JCV

Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495 (dimerization mode II)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (2)	Metabotropic glutamate receptor 2,Peptidyl-prolyl cis-trans isomerase FKBP1A	polymer	993	109340.9	1	UniProt (Q14416) UniProt (P62942) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003) Pfam (PF00254)	Homo sapiens (human)	mGluR2,PPIase FKBP1A,12 kDa FK506-binding protein,12 kDa FKBP,FKBP-12,Calstabin-1,FK506-binding protein 1A,FKBP-1A,Immunophilin FKBP12,Rotamase
2	B (3)	Metabotropic glutamate receptor 3,Serine/threonine-protein kinase mTOR	polymer	993	112713.0	1	UniProt (Q14832) UniProt (A0A8V8TRG9) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003) Pfam (PF08771)	Homo sapiens (human)
3	C, E (2, 3)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
4	D, F (2, 3)	2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine	non-polymer		353.4	2	Chemie (Z99) PubChem (44300270) PubChem (44348804) PubChem (57824323) PubChem (4364840) PubChem (69351741) PubChem (68198047) PubChem (89651894) PubChem (6604829) PubChem (9819927) PubChem (9975366) PubChem (10618042) PubChem (10713043) PubChem (10807972) PubChem (138113521) PubChem (156758060) PubChem (163320174) PubChem (169545577) PubChem (171041419)

Sequence modifications

2: 19 - 872 (UniProt: Q14416)

PDB	External Database	Details
Asp 9	-	expression tag
Tyr 10	-	expression tag
Lys 11	-	expression tag
Asp 12	-	expression tag
Asp 13	-	expression tag
Asp 14	-	expression tag
Asp 15	-	expression tag
Gly 16	-	expression tag
Ala 17	-	expression tag
Pro 18	-	expression tag
Ala 555	Glu 555	conflict
Leu 873	-	linker
Glu 874	-	linker
Val 875	-	linker
Leu 876	-	linker
Phe 877	-	linker
Gln 878	-	linker
Gly 879	-	linker
Pro 880	-	linker
Gly 881	-	linker
Val 882	-	linker
Gln 883	-	linker
Val 884	-	linker
Glu 885	-	linker
Thr 886	-	linker
Ile 887	-	linker
Ser 888	-	linker
Pro 889	-	linker
Gly 890	-	linker
Asp 891	-	linker
Gly 892	-	linker
Arg 893	-	linker
Thr 894	-	linker
Phe 895	-	linker
Pro 896	-	linker

2: 897 - 987 (UniProt: P62942)

PDB	External Database	Details
Phe 988	-	expression tag
Ala 989	-	expression tag
Ala 990	-	expression tag
Ala 991	-	expression tag
His 992	-	expression tag
His 993	-	expression tag
His 994	-	expression tag
His 995	-	expression tag
His 996	-	expression tag
His 997	-	expression tag
His 998	-	expression tag
His 999	-	expression tag
His 1000	-	expression tag
His 1001	-	expression tag

3: 23 - 879 (UniProt: Q14832)

PDB	External Database	Details
Asp -8	-	expression tag
Tyr -7	-	expression tag
Lys -6	-	expression tag
Asp -5	-	expression tag
Asp -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Lys -1	-	expression tag
Gly 0	-	expression tag
Ala 1	-	expression tag
Pro 2	-	expression tag
Trp 3	-	expression tag
Ser 4	-	expression tag
His 5	-	expression tag
Pro 6	-	expression tag
Gln 7	-	expression tag
Phe 8	-	expression tag
Glu 9	-	expression tag
Lys 10	-	expression tag
Gly 11	-	expression tag
Ser 12	-	expression tag
Gly 13	-	expression tag
Ser 14	-	expression tag
Trp 15	-	expression tag
Ser 16	-	expression tag
His 17	-	expression tag
Pro 18	-	expression tag
Gln 19	-	expression tag
Phe 20	-	expression tag
Glu 21	-	expression tag
Lys 22	-	expression tag
Leu 880	-	linker
Glu 881	-	linker
Val 882	-	linker
Leu 883	-	linker
Phe 884	-	linker
Gln 885	-	linker
Gly 886	-	linker
Pro 887	-	linker

3: 888 - 982 (UniProt: A0A8V8TRG9)

PDB	External Database	Details
Glu 983	-	expression tag
Phe 984	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	222053.8
Non-Polymers*	Number of molecules	4
	Total formula weight	1149.2
All*	Total formula weight	223203.0

*Water molecules are not included.