8J9X

Cryo-EM structure of the African swine fever virus topoisomerase 2 complexed with Cut02aDNA and m-AMSA (EDI-3)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	DNA topoisomerase 2	polymer	1197	136422.6	2	UniProt (A0A0A1E3Q0) Pfam (PF16898) Pfam (PF00521) UniProt (by SIFTS) (Q00942) In PDB	African swine fever virus
2	C, E	DNA (5'-D(*GP*AP*GP*GP*TP*AP*TP*GP*TP*AP*GP*GP*C)-3')	polymer	13	4071.7	2		Homo sapiens
3	D, F	DNA (5'-D(*GP*GP*CP*CP*GP*CP*CP*TP*AP*CP*AP*TP*AP*CP*CP*TP*C)-3')	polymer	17	5108.3	2		Homo sapiens
4	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
5	D, F	N-[4-(acridin-9-ylamino)-3-methoxyphenyl]methanesulfonamide	non-polymer		393.5	2	Chemie (ASW)

Sequence modifications

A, B: 1 - 1192 (UniProt: A0A0A1E3Q0)

PDB	External Database	Details
His 1193	-	expression tag
His 1194	-	expression tag
His 1195	-	expression tag
His 1196	-	expression tag
His 1197	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	291205.1
Non-Polymers*	Number of molecules	4
	Total formula weight	835.5
All*	Total formula weight	292040.6

*Water molecules are not included.