8J86
Monkeypox virus DNA replication holoenzyme F8, A22 and E4 complex in a DNA binding form
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | DNA polymerase | polymer | 1029 | 120041.2 | 1 | UniProt (Q5IXW8) Pfam (PF08452) Pfam (PF03104) Pfam (PF08408) Pfam (PF00136) UniProt (by SIFTS) (A0A7H0DN44) In PDB | Monkeypox virus | Mpox DNA polymerase F8 |
2 | B | E4R | polymer | 241 | 27883.7 | 1 | UniProt (Q5IXS4) UniProt (by SIFTS) (M1LL92) In PDB | Monkeypox virus | |
3 | C | DNA polymerase processivity factor component A20 | polymer | 426 | 49203.9 | 1 | UniProt (Q5IXP2) Pfam (PF05941) UniProt (by SIFTS) (A0A7H0DNC0) In PDB | Monkeypox virus | |
4 | P | DNA (5'-D(P*AP*GP*CP*TP*GP*CP*TP*AP*TP*GP*TP*GP*AP*GP*AP*TP*TP*AP*AP*GP*TP*TP*AP*T)-3') | polymer | 24 | 7438.8 | 1 | DNA molecule | ||
5 | T | DNA (5'-D(P*GP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*GP*AP*TP*AP*AP*CP*TP*TP*AP*AP*TP*CP*TP*CP*AP*CP*AP*TP*AP*GP*CP*AP*GP*CP*TP*)-3') | polymer | 38 | 11605.5 | 1 | DNA molecule | ||
6 | A | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) |
Sequence modifications
A: 1 - 1006 (UniProt: Q5IXW8)
B: 1 - 218 (UniProt: Q5IXS4)
PDB | External Database | Details |
---|---|---|
Met -22 | - | initiating methionine |
His -21 | - | expression tag |
His -20 | - | expression tag |
His -19 | - | expression tag |
His -18 | - | expression tag |
His -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
Asp -13 | - | expression tag |
Tyr -12 | - | expression tag |
Asp -11 | - | expression tag |
Ile -10 | - | expression tag |
Pro -9 | - | expression tag |
Thr -8 | - | expression tag |
Thr -7 | - | expression tag |
Glu -6 | - | expression tag |
Asn -5 | - | expression tag |
Leu -4 | - | expression tag |
Tyr -3 | - | expression tag |
Phe -2 | - | expression tag |
Gln -1 | - | expression tag |
Gly 0 | - | expression tag |
Phe 108 | Leu 108 | engineered mutation |
Leu 411 | Trp 411 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -22 | - | initiating methionine |
His -21 | - | expression tag |
His -20 | - | expression tag |
His -19 | - | expression tag |
His -18 | - | expression tag |
His -17 | - | expression tag |
His -16 | - | expression tag |
Asp -15 | - | expression tag |
Tyr -14 | - | expression tag |
Asp -13 | - | expression tag |
Ile -12 | - | expression tag |
Pro -11 | - | expression tag |
Thr -10 | - | expression tag |
Thr -9 | - | expression tag |
Glu -8 | - | expression tag |
Asn -7 | - | expression tag |
Leu -6 | - | expression tag |
Tyr -5 | - | expression tag |
Phe -4 | - | expression tag |
Gln -3 | - | expression tag |
Gly -2 | - | expression tag |
Ala -1 | - | expression tag |
Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 216173.1 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 120.2 | |
All* | Total formula weight | 216293.3 |