8J5X
The crystal structure of TrkA(G595R) kinase in complex with N-(3-cyclopropyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-4^6-methyl-14-oxo-5-oxa-13-aza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclotetradecaphan-2-yne-4^5-carboxamide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | High affinity nerve growth factor receptor | polymer | 299 | 34007.3 | 1 | UniProt (P04629) Pfam (PF07714) In PDB | Homo sapiens (human) | Neurotrophic tyrosine kinase receptor type 1,TRK1-transforming tyrosine kinase protein,Tropomyosin-related kinase A,Tyrosine kinase receptor,Tyrosine kinase receptor A,Trk-A,gp140trk,p140-TrkA |
2 | A | N-(3-cyclopropyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-4^6-methyl-14-oxo-5-oxa-13-aza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclotetradecaphan-2-yne-4^5-carboxamide | non-polymer | 659.8 | 1 | Chemie (A4U) | |||
3 | water | water | 18.0 | 200 | Chemie (HOH) |
Sequence modifications
A: 498 - 796 (UniProt: P04629)
PDB | External Database | Details |
---|---|---|
Arg 595 | Gly 595 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 34007.3 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 659.8 | |
All* | Total formula weight | 34667.1 |