8J5X
The crystal structure of TrkA(G595R) kinase in complex with N-(3-cyclopropyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-4^6-methyl-14-oxo-5-oxa-13-aza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclotetradecaphan-2-yne-4^5-carboxamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | High affinity nerve growth factor receptor | polymer | 299 | 34007.3 | 1 | UniProt (P04629) Pfam (PF07714) | Homo sapiens (human) | Neurotrophic tyrosine kinase receptor type 1,TRK1-transforming tyrosine kinase protein,Tropomyosin-related kinase A,Tyrosine kinase receptor,Tyrosine kinase receptor A,Trk-A,gp140trk,p140-TrkA |
| 2 | B (A) | N-(3-cyclopropyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-4^6-methyl-14-oxo-5-oxa-13-aza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclotetradecaphan-2-yne-4^5-carboxamide | non-polymer | 659.8 | 1 | Chemie (A4U) | |||
| 3 | C (A) | water | water | 18.0 | 200 | Chemie (HOH) |
Sequence modifications
A: 498 - 796 (UniProt: P04629)
| PDB | External Database | Details |
|---|---|---|
| Arg 595 | Gly 595 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34007.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 659.8 | |
| All* | Total formula weight | 34667.1 |
