8J37
Crystal structure of SARS-Cov-2 main protease K90R mutant in complex with PF00835231
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | 3C-like proteinase nsp5 | polymer | 299 | 33176.8 | 2 | UniProt (P0DTC1) Pfam (PF05409) UniProt (by SIFTS) (P0DTD1) In PDB | Severe acute respiratory syndrome coronavirus 2 | 3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase |
2 | A, B | N-[(2S)-1-({(2S,3S)-3,4-dihydroxy-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl}amino)-4-methyl-1-oxopentan-2-yl]-4-methoxy-1H-indole-2-carboxamide | non-polymer | 474.6 | 2 | Chemie (V2M) | |||
3 | water | water | 18.0 | 105 | Chemie (HOH) |
Sequence modifications
A, B: 3 - 301 (UniProt: P0DTC1)
PDB | External Database | Details |
---|---|---|
Arg 90 | Lys 3353 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 66353.7 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 949.1 | |
All* | Total formula weight | 67302.8 |