8J26

CryoEM structure of SARS CoV-2 RBD and Aptamer complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (E)	AM032-4	polymer	44	15288.5	1		synthetic construct
2	B (A)	Fab light chain (REGN10987)	polymer	224	23909.3	1		Homo sapiens (human)
3	C (B)	Fab heavy chain (REGN10987)	polymer	248	26705.9	1		Homo sapiens (human)
4	D (C)	Spike protein S1	polymer	253	28415.7	1	UniProt (P0DTC2) Pfam (PF09408)	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2)
5	E (D)	AM047-6	polymer	48	16446.1	1		synthetic construct
6	F (C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)

Sequence modifications

C: 319 - 541 (UniProt: P0DTC2)

PDB	External Database	Details
Glu 542	-	expression tag
Asn 543	-	expression tag
Leu 544	-	expression tag
Tyr 545	-	expression tag
Phe 546	-	expression tag
Gln 547	-	expression tag
Gly 548	-	expression tag
Ala 549	-	expression tag
Ala 550	-	expression tag
Ala 551	-	expression tag
Gly 552	-	expression tag
Gly 553	-	expression tag
Ser 554	-	expression tag
His 555	-	expression tag
His 556	-	expression tag
His 557	-	expression tag
His 558	-	expression tag
His 559	-	expression tag
His 560	-	expression tag
Gly 561	-	expression tag
Gly 562	-	expression tag
Ser 563	-	expression tag
Asp 564	-	expression tag
Tyr 565	-	expression tag
Lys 566	-	expression tag
Asp 567	-	expression tag
Asp 568	-	expression tag
Asp 569	-	expression tag
Asp 570	-	expression tag
Lys 571	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	110765.5
Non-Polymers*	Number of molecules	1
	Total formula weight	221.2
All*	Total formula weight	110986.7

*Water molecules are not included.