8J23
Cryo-EM structure of FFAR2 complex in apo state
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Free fatty acid receptor 2 | polymer | 311 | 35256.6 | 1 | UniProt (O15552) Pfam (PF00001) In PDB | Homo sapiens (human) | G-protein coupled receptor 43 |
2 | B | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40415.0 | 1 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
3 | C | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 377 | 41055.9 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
4 | D | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
5 | F | scFV16 | polymer | 297 | 31870.6 | 1 | Homo sapiens (human) |
Sequence modifications
A: 1 - 310 (UniProt: O15552)
C: 0 - 338 (UniProt: P62873)
PDB | External Database | Details |
---|---|---|
Thr 2 | Leu 2 | conflict |
Val 36 | Ile 36 | conflict |
Ile 80 | Val 80 | variant |
Gly 86 | Ser 86 | conflict |
Asn 148 | Ser 158 | variant |
Glu 170 | Asn 171 | conflict |
Thr 207 | Ser 208 | conflict |
His 210 | Leu 211 | variant |
Phe 245 | Tyr 246 | variant |
Tyr 246 | His 247 | conflict |
Leu 289 | Val 290 | conflict |
PDB | External Database | Details |
---|---|---|
Met -12 | - | initiating methionine |
His -11 | - | expression tag |
His -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
Gly -5 | - | expression tag |
Ser -4 | - | expression tag |
Leu -3 | - | expression tag |
Leu -2 | - | expression tag |
Gln -1 | - | expression tag |
Gly 339 | - | expression tag |
Ser 340 | - | expression tag |
Ser 341 | - | expression tag |
Gly 342 | - | expression tag |
Gly 343 | - | expression tag |
Gly 344 | - | expression tag |
Gly 345 | - | expression tag |
Ser 346 | - | expression tag |
Gly 347 | - | expression tag |
Gly 348 | - | expression tag |
Gly 349 | - | expression tag |
Gly 350 | - | expression tag |
Ser 351 | - | expression tag |
Ser 352 | - | expression tag |
Gly 353 | - | expression tag |
Val 354 | - | expression tag |
Ser 355 | - | expression tag |
Gly 356 | - | expression tag |
Trp 357 | - | expression tag |
Arg 358 | - | expression tag |
Leu 359 | - | expression tag |
Phe 360 | - | expression tag |
Lys 361 | - | expression tag |
Lys 362 | - | expression tag |
Ile 363 | - | expression tag |
Ser 364 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 156459.3 | |
All* | Total formula weight | 156459.3 |