8J21
Cryo-EM structure of FFAR3 complex bound with butyrate acid
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 377 | 41055.9 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
2 | B | scFV16 | polymer | 297 | 31870.6 | 1 | Homo sapiens (human) | ||
3 | C | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40415.0 | 1 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
4 | D | Free fatty acid receptor 3 | polymer | 314 | 35432.6 | 1 | UniProt (O14843) Pfam (PF00001) In PDB | Homo sapiens (human) | G-protein coupled receptor 41 |
5 | E | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
6 | D | butanoic acid | non-polymer | 88.1 | 1 | Chemie (BUA) |
Sequence modifications
A: 13 - 351 (UniProt: P62873)
D: 1 - 314 (UniProt: O14843)
PDB | External Database | Details |
---|---|---|
Met 1 | - | initiating methionine |
His 2 | - | expression tag |
His 3 | - | expression tag |
His 4 | - | expression tag |
His 5 | - | expression tag |
His 6 | - | expression tag |
His 7 | - | expression tag |
Gly 8 | - | expression tag |
Ser 9 | - | expression tag |
Leu 10 | - | expression tag |
Leu 11 | - | expression tag |
Gln 12 | - | expression tag |
Gly 352 | - | expression tag |
Ser 353 | - | expression tag |
Ser 354 | - | expression tag |
Gly 355 | - | expression tag |
Gly 356 | - | expression tag |
Gly 357 | - | expression tag |
Gly 358 | - | expression tag |
Ser 359 | - | expression tag |
Gly 360 | - | expression tag |
Gly 361 | - | expression tag |
Gly 362 | - | expression tag |
Gly 363 | - | expression tag |
Ser 364 | - | expression tag |
Ser 365 | - | expression tag |
Gly 366 | - | expression tag |
Val 367 | - | expression tag |
Ser 368 | - | expression tag |
Gly 369 | - | expression tag |
Trp 370 | - | expression tag |
Arg 371 | - | expression tag |
Leu 372 | - | expression tag |
Phe 373 | - | expression tag |
Lys 374 | - | expression tag |
Lys 375 | - | expression tag |
Ile 376 | - | expression tag |
Ser 377 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ser 4 | Gly 4 | variant |
Phe 9 | Tyr 9 | conflict |
Pro 11 | Ser 11 | conflict |
Leu 16 | Phe 16 | conflict |
Phe 23 | Leu 23 | conflict |
Ile 38 | Val 38 | variant |
Arg 44 | Gln 44 | variant |
Leu 59 | Ala 59 | conflict |
Ser 77 | Asn 77 | variant |
Leu 94 | Ile 94 | conflict |
Tyr 119 | His 119 | variant |
Glu 175 | Lys 175 | conflict |
Gly 194 | Val 194 | conflict |
Leu 198 | Ile 198 | conflict |
Ala 215 | Gly 215 | conflict |
Arg 220 | Gln 220 | conflict |
Val 227 | Leu 227 | variant |
Gln 251 | Cys 251 | conflict |
Val 256 | Ala 256 | variant |
Ser 259 | Ile 259 | conflict |
Leu 262 | Thr 262 | conflict |
Leu 274 | Phe 274 | conflict |
Pro 300 | Gln 300 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 156635.2 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 88.1 | |
All* | Total formula weight | 156723.3 |