8J1B
GSK101 and Ruthenium Red bound state of mTRPV4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Transient receptor potential cation channel subfamily V member 4 | polymer | 700 | 79611.7 | 4 | UniProt (Q9EPK8) Pfam (PF00023) Pfam (PF00520) In PDB | Mus musculus (house mouse) | TrpV4,Osm-9-like TRP channel 4,OTRPC4,Transient receptor potential protein 12,TRP12,Vanilloid receptor-like channel 2,Vanilloid receptor-like protein 2,Vanilloid receptor-related osmotically-activated channel,VR-OAC |
| 2 | A, B, C, D | N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide | non-polymer | 655.6 | 4 | Chemie (XQ3) | |||
| 3 | A | ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2) | non-polymer | 559.5 | 1 | Chemie (R2R) |
Sequence modifications
A, B, C, D: 137 - 801 (UniProt: Q9EPK8)
| PDB | External Database | Details |
|---|---|---|
| Asp 102 | - | expression tag |
| Tyr 103 | - | expression tag |
| Lys 104 | - | expression tag |
| Asp 105 | - | expression tag |
| Asp 106 | - | expression tag |
| Asp 107 | - | expression tag |
| Asp 108 | - | expression tag |
| Lys 109 | - | expression tag |
| Trp 110 | - | expression tag |
| Ser 111 | - | expression tag |
| His 112 | - | expression tag |
| Pro 113 | - | expression tag |
| Gln 114 | - | expression tag |
| Phe 115 | - | expression tag |
| Glu 116 | - | expression tag |
| Lys 117 | - | expression tag |
| Gly 118 | - | expression tag |
| Gly 119 | - | expression tag |
| Gly 120 | - | expression tag |
| Gly 121 | - | expression tag |
| Ser 122 | - | expression tag |
| Gly 123 | - | expression tag |
| Gly 124 | - | expression tag |
| Ser 125 | - | expression tag |
| Ala 126 | - | expression tag |
| Trp 127 | - | expression tag |
| Ser 128 | - | expression tag |
| His 129 | - | expression tag |
| Pro 130 | - | expression tag |
| Gln 131 | - | expression tag |
| Phe 132 | - | expression tag |
| Glu 133 | - | expression tag |
| Lys 134 | - | expression tag |
| Glu 135 | - | expression tag |
| Phe 136 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 318446.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 3182.0 | |
| All* | Total formula weight | 321628.7 |
