8J01
Human KCNQ2-CaM in complex with CBD and PIP2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, D, F (A, B, D, G) | Potassium voltage-gated channel subfamily KQT member 2 | polymer | 656 | 73627.8 | 4 | UniProt (O43526) Pfam (PF00520) Pfam (PF07885) Pfam (PF03520) Pfam (PF16642) | Homo sapiens (human) | KQT-like 2,Neuroblastoma-specific potassium channel subunit alpha KvLQT2,Voltage-gated potassium channel subunit Kv7.2 |
| 2 | C, E, G, H (C, F, H, E) | Calmodulin-1 | polymer | 177 | 19615.4 | 4 | UniProt (P0DP23) Pfam (PF13499) | Homo sapiens (human) | |
| 3 | I, J, M, N, O... (A, B, D, G) | cannabidiol | non-polymer | 314.5 | 8 | Chemie (P0T) | |||
| 4 | K, L, Q, T (A, B, D, G) | [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | non-polymer | 746.6 | 4 | Chemie (PIO) |
Sequence modifications
A, B, D, G: 64 - 702 (UniProt: O43526)
C, F, H, E: 1 - 149 (UniProt: P0DP23)
| PDB | External Database | Details |
|---|---|---|
| Met 63 | - | initiating methionine |
| Val 703 | - | expression tag |
| Glu 704 | - | expression tag |
| Gly 705 | - | expression tag |
| Gly 706 | - | expression tag |
| Ser 707 | - | expression tag |
| Ser 708 | - | expression tag |
| Gly 709 | - | expression tag |
| Gly 710 | - | expression tag |
| Trp 711 | - | expression tag |
| Ser 712 | - | expression tag |
| His 713 | - | expression tag |
| Pro 714 | - | expression tag |
| Gln 715 | - | expression tag |
| Phe 716 | - | expression tag |
| Glu 717 | - | expression tag |
| Lys 718 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Leu 150 | - | expression tag |
| Glu 151 | - | expression tag |
| Gly 152 | - | expression tag |
| Gly 153 | - | expression tag |
| Ser 154 | - | expression tag |
| Ser 155 | - | expression tag |
| Gly 156 | - | expression tag |
| Gly 157 | - | expression tag |
| Leu 158 | - | expression tag |
| Val 159 | - | expression tag |
| Pro 160 | - | expression tag |
| Arg 161 | - | expression tag |
| Gly 162 | - | expression tag |
| Ser 163 | - | expression tag |
| Gly 164 | - | expression tag |
| Gly 165 | - | expression tag |
| Ser 166 | - | expression tag |
| Ser 167 | - | expression tag |
| Gly 168 | - | expression tag |
| Gly 169 | - | expression tag |
| His 170 | - | expression tag |
| His 171 | - | expression tag |
| His 172 | - | expression tag |
| His 173 | - | expression tag |
| His 174 | - | expression tag |
| His 175 | - | expression tag |
| His 176 | - | expression tag |
| His 177 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 372973.0 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 5502.0 | |
| All* | Total formula weight | 378475.0 |
