8IZ7

cryo-EM structure of sulindac-bound hMRP4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	ATP-binding cassette sub-family C member 4	polymer	1357	153171.4	1	UniProt (O15439) Pfam (PF00664) Pfam (PF00005)	Homo sapiens (human)	MRP/cMOAT-related ABC transporter,Multi-specific organic anion transporter B,MOAT-B,Multidrug resistance-associated protein 4
2	B (A)	[(1Z)-5-fluoro-2-methyl-1-{4-[methylsulfinyl]benzylidene}-1H-inden-3-yl]acetic acid	non-polymer		356.4	1	Chemie (SUZ)

Sequence modifications

A: 1 - 1325 (UniProt: O15439)

PDB	External Database	Details
Leu 1326	-	expression tag
Glu 1327	-	expression tag
Gly 1328	-	expression tag
Gly 1329	-	expression tag
Gly 1330	-	expression tag
Ser 1331	-	expression tag
Gly 1332	-	expression tag
Gly 1333	-	expression tag
Gly 1334	-	expression tag
Ser 1335	-	expression tag
Asp 1336	-	expression tag
Tyr 1337	-	expression tag
Lys 1338	-	expression tag
Asp 1339	-	expression tag
His 1340	-	expression tag
Asp 1341	-	expression tag
Gly 1342	-	expression tag
Asp 1343	-	expression tag
Tyr 1344	-	expression tag
Lys 1345	-	expression tag
Asp 1346	-	expression tag
His 1347	-	expression tag
Asp 1348	-	expression tag
Ile 1349	-	expression tag
Asp 1350	-	expression tag
Tyr 1351	-	expression tag
Lys 1352	-	expression tag
Asp 1353	-	expression tag
Asp 1354	-	expression tag
Asp 1355	-	expression tag
Asp 1356	-	expression tag
Lys 1357	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	153171.4
Non-Polymers*	Number of molecules	1
	Total formula weight	356.4
All*	Total formula weight	153527.8

*Water molecules are not included.