8IXS
Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1/Nrf2 PPI Inhibitor for Treatment of Chronic Kidney Disease
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Kelch-like ECH-associated protein 1 | polymer | 315 | 34730.0 | 1 | UniProt (Q14145) Pfam (PF01344) | Homo sapiens (human) | Cytosolic inhibitor of Nrf2,INrf2,Kelch-like protein 19 |
| 2 | B (A) | (2R,3S)-3-[[(2S)-2-fluoranyl-2-(5,6,7,8-tetrahydronaphthalen-2-yl)ethanoyl]amino]-2-methyl-3-(4-methylphenyl)propanoic acid | non-polymer | 383.5 | 1 | Chemie (T6I) | |||
| 3 | C, D, E, F, G... (A) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 4 | I (A) | water | water | 18.0 | 426 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34730.0 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 959.8 | |
| All* | Total formula weight | 35689.9 |
