8IVG
Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1/Nrf2 PPI Inhibitor for Treatment of Chronic Kidney Disease
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Kelch-like ECH-associated protein 1 | polymer | 315 | 34730.0 | 1 | UniProt (Q14145) Pfam (PF01344) | Homo sapiens (human) | Cytosolic inhibitor of Nrf2,INrf2,Kelch-like protein 19 |
| 2 | B (A) | (3S)-3-(4-methylphenyl)-3-[2-(5,6,7,8-tetrahydronaphthalen-2-yl)ethanoylamino]propanoic acid | non-polymer | 351.4 | 1 | Chemie (SGO) | |||
| 3 | C (A) | 2,3-DIHYDROXY-1,4-DITHIOBUTANE | non-polymer | 154.3 | 1 | Chemie (DTT) | |||
| 4 | D, E, F, G, H... (A) | SULFATE ION | non-polymer | 96.1 | 9 | Chemie (SO4) | |||
| 5 | M (A) | water | water | 18.0 | 261 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34730.0 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1370.3 | |
| All* | Total formula weight | 36100.3 |
