8IUM
Cryo-EM structure of the tafluprost acid-bound human PTGFR-Gq complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | G subunit alpha (q) | polymer | 361 | 41724.4 | 1 | Homo sapiens (human) | ||
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 343 | 37771.4 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | |
| 3 | C (E) | Antibody fragment scFv16 | polymer | 247 | 26277.3 | 1 | Mus musculus | ||
| 4 | D (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 5 | E (N) | nanobody Nb35 | polymer | 150 | 16097.2 | 1 | Lama glama | ||
| 6 | F (R) | Prostaglandin F2-alpha receptor | polymer | 359 | 40096.5 | 1 | UniProt (P43088) Pfam (PF00001) | Homo sapiens (human) | PGF receptor,PGF2-alpha receptor,Prostanoid FP receptor |
| 7 | G (R) | (~{Z})-7-[(1~{R},2~{R},3~{R},5~{S})-2-[(~{E})-3,3-bis(fluoranyl)-4-phenoxy-but-1-enyl]-3,5-bis(oxidanyl)cyclopentyl]hept-5-enoic acid | non-polymer | 410.5 | 1 | Chemie (S2F) |
Sequence modifications
B: 7 - 345 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Met 3 | - | initiating methionine |
| Leu 4 | - | expression tag |
| Leu 5 | - | expression tag |
| Gln 6 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 169827.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 410.5 | |
| All* | Total formula weight | 170238.3 |
